PT  - JOURNAL ARTICLE
AU  - Hiroyoshi Yamauchi
AU  - Masashi Bando
AU  - Tomohisa Baba
AU  - Kensuke Kataoka
AU  - Yoshikazu Inoue
AU  - Yoshihito Yamada
AU  - Hiroshi Yamamoto
AU  - Kentaro Watanabe
AU  - Yasuhiro Terasaki
AU  - Akira Hebisawa
AU  - Yoshinori Kawabata
AU  - Takeshi Johkoh
AU  - Fumikazu Sakai
AU  - Yukihiko Sugiyama
AU  - Takashi Ogura
TI  - Clinical course and changes in high-resolution computed tomography findings in patients with idiopathic pulmonary fibrosis without honeycombing
AID  - 10.1183/13993003.congress-2015.PA4848
DP  - 2015 Sep 01
TA  - European Respiratory Journal
PG  - PA4848
VI  - 46
IP  - suppl 59
4099  - http://erj.ersjournals.com/content/46/suppl_59/PA4848.short
4100  - http://erj.ersjournals.com/content/46/suppl_59/PA4848.full
SO  - Eur Respir J2015 Sep 01; 46
AB  - Background: Some idiopathic pulmonary fibrosis (IPF) patients are histologically diagnosed with usual interstitial pneumonia (UIP) pattern and show lack of honeycombing on high resolution computed tomography (HRCT) . Clinical course and the changes in HRCT findings of these IPF patients are unknown.Aims and objectives: The purpose of our study was to retrospectively assess the changes in HRCT pattern in IPF patients, who were diagnosed with UIP pattern by histology and show lack of honeycombing by HRCT in initial evaluation, and to clarify their clinical course and prognosis.Methods: We evaluated IPF patients without honeycombing on HRCT and who were histologically diagnosed with UIP pattern on the basis of surgical lung biopsy between 1991 and 2010. Multidisciplinary discussions were held 5 times between 2011 and 2014 to evaluate the disease changes as assessed by HRCT and clinical course of these patients.Results: Thirty patients were evaluated by 2014. Sixteen patients demonstrated emerging honeycombing (Group A) and 12 patients demonstrated emerging traction bronchiectasis or cyst without honeycombing (Group B) by HRCT. Two cases were considered as no change (Group C) by HRCT. The mean survival times of Groups A and B were 67.1 and 61.2 months which were not significantly different (p=0.76) .Conclusions: Some IPF patients may not demonstrate honeycombing on HRCT even if they have advanced stage IPF. Our study suggests that there is no difference in prognosis of IPF between cases with honeycombing on HRCT and those without.