PT  - JOURNAL ARTICLE
AU  - Thomas Bronsveld
AU  - Emanuel Citgez
AU  - Robin Bruggink
AU  - Onno Mennes
AU  - Frans De Jongh
AU  - Marjolein Brusse-Keizer
AU  - Hugo Schouwink
TI  - Volume quantification of malignant pleural mesothelioma
AID  - 10.1183/13993003.congress-2015.PA4348
DP  - 2015 Sep 01
TA  - European Respiratory Journal
PG  - PA4348
VI  - 46
IP  - suppl 59
4099  - http://erj.ersjournals.com/content/46/suppl_59/PA4348.short
4100  - http://erj.ersjournals.com/content/46/suppl_59/PA4348.full
SO  - Eur Respir J2015 Sep 01; 46
AB  - Purpose: The prognosis of malignant pleural mesothelioma (MPM) is poor and most prognostic factors are inconsistent. PET/CT provides a measure of the metabolic activity of the tumor. Therefore, we evaluated the prognostic value of parameters derived from PET/CT, produced by our new developed tool.Methods: PET/CT images of 38 patients, from three institutions, with MPM who underwent PET/CT prior to treatment were retrospectively semi-automatically analyzed. The measured parameters included; mean, maximum and peak standardized uptake values (SUV), metabolic tumor volume (MTV) and total lesion glycolysis (TLG, the tumor volume multiplied by its mean SUV).Results: Median survival was 9.9 months after diagnosis. Univariate Cox regression showed that SUVmax (HR=1.05), SUVpeak (HR=1.05), TLG (HR=1.15) and MTV (HR=1.13) are significant predictors for overall survival. Kaplan-Meier analyses showed significant difference in survival when MTV and TLG were grouped based on their median value.Conclusion: A new developed software tool showed that SUVmax, SUVpeak, TLG and MTV are all significant PET/CT parameters to predict survival in patients with malignant pleural mesothelioma. A prospective study should be performed to asses the possibility for chemotherapy response monitoring using this tool.