RT Journal Article SR Electronic T1 Malignant pleural effusion (MPE) as debut of cancer JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP PA4345 DO 10.1183/13993003.congress-2015.PA4345 VO 46 IS suppl 59 A1 Ismael Ali García A1 Beatriz Morales Chacón A1 Nuria Abad Santamaría A1 Maria Teresa Río Ramirez A1 María Isabel Verdugo Cartas A1 Raquel Pérez Rojo A1 Eva De Santiago Delgado A1 Yolanda Martínez Abad A1 Bárbara Steen A1 Mercedes Izquierdo Patrón A1 Rosario Melchor Iñiguez A1 José Ignacio De Granda Orive A1 María Beatriz Arias Arcos A1 Victoria Villena Garrido YR 2015 UL http://erj.ersjournals.com/content/46/suppl_59/PA4345.abstract AB Introduction and Objective: To evaluate the clinical manifestations, diagnostic techniques, histology and location of the primary tumor of patients with MPE as debut of cancer.Methods: 402 consecutive patients diagnosed of malignant pleural effusion as debut of cancer were studied retrospectively (2008-2013) in a multi-centric study.Results: median age 70 years, 241 males. Main symptoms were dyspnea 81.1%, chest pain 47.8%, cough 44.3%, weight loss 36.6%, extrathoracic symptoms 34%, fever 9.2 and hemoptysis 2.2%. The location of the primary tumor was: lung 53.5%, pleural 20.4%, gynecological 6.5%, haematological 6.5%, gastrointestinal 3.2%, breast 1%, urological 7.9%, unknown 1%. The histologycal type were: adenocarcinoma 58%, mesothelioma 18,9%, carcinoma 7.2%, lymphoma 5.2%, small cell 5%, non small cell 2.46%, squamous cell carcinoma 1.5%, leukemia 1.24% and sarcoma 0.5%.TechniqueThoracocentesis (A)closed pleural biopsy (B)Pleural biopsy ultrasound-assisted (C)thoracoscopy (D)thoracotomy (E)Number (%)400 (99,5)138 (34.3)36 (9)69 (22,9)4 (1)Yield67,5%48,5%55,5%100%100%Screening for malignancy242(60,3%)44 (10.9%)15 (3.7%)69 (17.2%)4 (1%)(A)+(B) 23 (5.7%)(A)+(C) 5 (1.2%)The diagnostic techniques were:Conclusions: The MPE as a diagnosis of unknown primary tumor was more common in men of advanced age. The predominant symptom was dyspnea. The thoracentesis was higher diagnosis yield than the closed pleural biopsy. Pleural mesothelioma and lung adenocarcinoma histologic subtypes were the most common sites.