TY - JOUR T1 - Efficacy of talc slurry pleurodesis in malignant pleural effusions JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2015.PA4341 VL - 46 IS - suppl 59 SP - PA4341 AU - Pedro Silva Santos AU - Maria Alcide Marques AU - Hugo Monteiro AU - Fátima Fradinho Y1 - 2015/09/01 UR - http://erj.ersjournals.com/content/46/suppl_59/PA4341.abstract N2 - Background: Malignant pleural effusions are an important burden of malignant disease. Slurry talc pleurodesis remains one of the most common and effective therapeutic options.Aim: To investigate the predictive factors related with the efficacy of this technique in malignant pleural effusions.Methods: Retrospective analysis of all pleurodesis performed during a 5-year period in a Pulmonology Unit. All demographic and clinical data were collected, including the histologic tumoral type and the biochemical, microbiological and cytological fluid features. Efficacy was defined as the lack of recurrence of pleural effusion. We used Kaplan-Meyer analysis to estimate overall survival. To identify factors affecting efficacy and survival we used univariate and multivariate analysis.Results: From a total of 146 patients submitted to pleurodesis, 110 (45.5% men; mean age 67.4±12.6 years) were included. Light's criteria identified 54.5% as exudates. Pleurodesis was effective in 67.3% of all cases. There was no statistically significant association between the following variables and pleurodesis efficacy: patients age and pleural and serum pH, LDH, protein, albumin, ADA and cytology. However, pleural glucose levels <60 mg/dL showed a borderline correlation with effectiveness (OR:0.203[0.046;0.984], IC95%). Survival was slightly different between the groups in which pleurodesis was effective and ineffective (mean 419.5±77.6 vs 156.8±27.8 days, respectively, p=0.054) and without any association with the tumor histology.Conclusions: Age or pleural features had no significant impact on pleurodesis efficacy. However, pleural glucose levels seem to be related with better outcomes. Transudates were unexpectedly frequent. ER -