TY - JOUR T1 - Asymmetric dimethylarginine contributes to airway nitric oxide deficiency in patients with COPD JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2015.PA4003 VL - 46 IS - suppl 59 SP - PA4003 AU - Murat Aydin AU - Nejat Altintas AU - Levent Mutlu AU - Bulent Bilir AU - Musatfa Oran AU - Feti Tukubas AU - Birol Topcu Y1 - 2015/09/01 UR - http://erj.ersjournals.com/content/46/suppl_59/PA4003.abstract N2 - Background: Asymmetric dimethylarginine (ADMA) and Nitric oxide (NO) show their mechanism of action reciprocally, thus the balance between these molecules contribute to the tight regulation of airways tone and function. The present study aims to determine the plasma levels of ADMA and NO in patients with chronic obstructive pulmonary disease (COPD) and establish whether their level vary in relation to forced expiratory volume in 1s (FEV1), to assess their role in pathophysiology of COPD.Materials and Methods: This study consisted of 58 patients with COPD and 30 healthy subjects. Plasma levels of ADMA and NO were measured using enzyme-linked immunosorbent assay and the colorimetric method respectively.Results: Plasma ADMA levels were significantly higher, however NO levels were lower in patients with COPD compared with healthy controls (p<0.001). Pearson correlation analysis showed that plasma ADMA levels were negatively correlated with NO levels (r=-0.625, p<0.001). Multivariable logistic regression analysis revealed that plasma NO levels were inversely, ADMA levels were directly, associated with the presence of COPD (odds ratio; 0.107 ; P=0.001 and odds ratio; 1.052; p<0.001 respectively). Multiple Linear regression analysis showed that COPD was positively associated with ADMA (p<0.001), however COPD and ADMA were independently and inversely associated with NO (p<0.001 and p = 0.009 respectively). NO levels were decreased, ADMA levels were increased compliant with progression of COPD stages which was measured by post-bronchodilator FEV1Conclusion: While circulating ADMA is higher, NO is lower in COPD and both show a strong correlation to the degree of airflow limitation. ER -