RT Journal Article SR Electronic T1 Role of 18F-FDG PET in Restrictive Allograft Syndrome after lung transplantation JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP OA3272 DO 10.1183/13993003.congress-2015.OA3272 VO 46 IS suppl 59 A1 Robin Vos A1 Stijn Verleden A1 Elly Vandermeulen A1 David Ruttens A1 Hannelore Bellon A1 Jonas Yserbyt A1 Lieven Dupont A1 Dirk Van Raemdonck A1 Olivier Gheysens A1 Nathalie De Raedt A1 Geert Verleden A1 Bart Vanaudenaerde YR 2015 UL http://erj.ersjournals.com/content/46/suppl_59/OA3272.abstract AB Introduction: Restrictive Allograft Syndrome (RAS) after lung transplantation (LTx) is characterized by a restrictive pulmonary function and peripheral consolidation and architectural deformation on CT. 18F-FDG PET imaging was investigated in RAS.Methods: Eighteen LTx recipients (8F/10M, age 49.7±12.6 y, 2 HLTx/2 SLTx/14 SSLTx, RAS diagnosis 6.2±2.9 y after LTx) were evaluated with PET at 0.3 (0.2-1.9) y after RAS diagnosis. Maximum standardized uptake value (SUVmax) was correlated with spirometric findings 3 mo. before (T-3), after (T+3) and at the time of PET (T0).Results: At T0, SUVmax (mean 2.86±1.96) inversely correlated with FVC (liters (L); p=0.014/r=-0.56) and FEV1 (L; p=0.0092/r=-0.59). SUVmax was also associated with the decrease in FVC (L; p=0.047/r=0.47) and FEV1 (L; p=0.012/r=0.56) from T-3 to T0.SUVmax was associated with the increase in FEV1/FVC (p=0.0044/r=0.72) from T0 to T+3 (figure). At T+3, SUVmax inversely correlated with FVC (L; p=0.0087/r=-0.67) and FEV1 (L; p=0.0014/r=-0.77), despite that spirometry could only be evaluated in 14/18 patients (2 died shortly after PET (SUVmax 6.01 and 8.20 respectively) and 2 with insufficient follow-up). SUVmax was higher in patients dying during follow-up (p=0.090/r=0.41; mean deceased 4.41±2.88 vs. alive 2.23±0.92; p=0.099).Conclusion: Metabolic activity on PET is associated with spirometry in RAS. Thus, PET may provide information regarding disease activity and prognosis in RAS.