TY - JOUR T1 - Role of 18<sup>F</sup>-FDG PET in Restrictive Allograft Syndrome after lung transplantation JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2015.OA3272 VL - 46 IS - suppl 59 SP - OA3272 AU - Robin Vos AU - Stijn Verleden AU - Elly Vandermeulen AU - David Ruttens AU - Hannelore Bellon AU - Jonas Yserbyt AU - Lieven Dupont AU - Dirk Van Raemdonck AU - Olivier Gheysens AU - Nathalie De Raedt AU - Geert Verleden AU - Bart Vanaudenaerde Y1 - 2015/09/01 UR - http://erj.ersjournals.com/content/46/suppl_59/OA3272.abstract N2 - Introduction: Restrictive Allograft Syndrome (RAS) after lung transplantation (LTx) is characterized by a restrictive pulmonary function and peripheral consolidation and architectural deformation on CT. 18F-FDG PET imaging was investigated in RAS.Methods: Eighteen LTx recipients (8F/10M, age 49.7±12.6 y, 2 HLTx/2 SLTx/14 SSLTx, RAS diagnosis 6.2±2.9 y after LTx) were evaluated with PET at 0.3 (0.2-1.9) y after RAS diagnosis. Maximum standardized uptake value (SUVmax) was correlated with spirometric findings 3 mo. before (T-3), after (T+3) and at the time of PET (T0).Results: At T0, SUVmax (mean 2.86±1.96) inversely correlated with FVC (liters (L); p=0.014/r=-0.56) and FEV1 (L; p=0.0092/r=-0.59). SUVmax was also associated with the decrease in FVC (L; p=0.047/r=0.47) and FEV1 (L; p=0.012/r=0.56) from T-3 to T0.SUVmax was associated with the increase in FEV1/FVC (p=0.0044/r=0.72) from T0 to T+3 (figure). At T+3, SUVmax inversely correlated with FVC (L; p=0.0087/r=-0.67) and FEV1 (L; p=0.0014/r=-0.77), despite that spirometry could only be evaluated in 14/18 patients (2 died shortly after PET (SUVmax 6.01 and 8.20 respectively) and 2 with insufficient follow-up). SUVmax was higher in patients dying during follow-up (p=0.090/r=0.41; mean deceased 4.41±2.88 vs. alive 2.23±0.92; p=0.099).Conclusion: Metabolic activity on PET is associated with spirometry in RAS. Thus, PET may provide information regarding disease activity and prognosis in RAS. ER -