TY - JOUR T1 - Influence of <em>mycobacterium tuberculosis</em> strains on recurrence of tuberculosis in Hanoi, Vietnam JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2015.PA3344 VL - 46 IS - suppl 59 SP - PA3344 AU - Nguyen T.L. Hang AU - Shinji Maeda AU - Takayuki Wada AU - Pham H. Thuong AU - Nguyen V. Hung AU - Vu C. Cuong AU - Nguyen P. Hoang AU - Shinsaku Sakurada AU - Minako Hijikata AU - Ikumi Matsushita AU - Luu T. Lien AU - Naoto Keicho Y1 - 2015/09/01 UR - http://erj.ersjournals.com/content/46/suppl_59/PA3344.abstract N2 - Background: Direct influence of Mycobacterium tuberculosis (Mtb) strains on recurrence of tuberculosis (TB) has not been fully investigated. We examined whether Mtb (sub)lineages and their subgroups including the Beijing genotype are associated with TB recurrence.Methods: After successful treatment using a standard regimen, 386 new smear/culture positive patients with pulmonary TB further entered a 16-month follow-up period to detect possible recurrence. Drug susceptibility testing and molecular genotyping including spoligotyping were performed on the Mtb isolates, which were further categorized into (sub)lineages and their subgroups based on their genomic variations.Results: The Mtb isolates were initially divided into the ancient (atypical) and modern (typical) Beijing genotype strains, and the non-Beijing strains including EAI spoligotypes. A major subgroup of the modern Beijing genotype strains characterized by five representative single nucleotide polymorphisms was observed in 39 (10.9%) of the 359 patients with no recurrence, and in 8 (29.6%) of the 27 patients with recurrence. Patients infected with this subgroup had a significantly shorter time to recurrence in our study population (P = 0.0028 by the log rank test), and even within the Beijing genotype strains (P = 0.0373). Even after adjustment for drug resistance using Cox proportional hazard models, this subgroup was significantly associated with recurrence in our study population (adjusted hazard ratio [aHR] = 3.77; 95% CI, 1.64−8.68), and also within the Beijing genotype strains (aHR = 3.08; 95% CI, 1.26−7.57).Conclusion: Further investigation of Mtb genotype-phenotype relationship is necessary for better TB management. ER -