RT Journal Article
SR Electronic
T1 Serum osteopontin as a prognostic marker in patients with lung cancer
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA4246
DO 10.1183/13993003.congress-2015.PA4246
VO 46
IS suppl 59
A1 Petta, Vasiliki
A1 Loukides, Stelios
A1 Kostikas, Konstantinos
A1 Papatheodorou, Georgios
A1 Cholidou, Kyriaki
A1 Tomos, Yiannis
A1 Papiris, Spyridon
A1 Koulouris, Nikolaos
A1 Bakakos, Petros
YR 2015
UL http://erj.ersjournals.com/content/46/suppl_59/PA4246.abstract
AB Introduction: Osteopontin (OPN) is a multifunctional cytokine that has been involved in cancer development, angiogenesis and metastasis. OPN is overexpressed in lung cancer and it has been evaluated as a biomarker of its progression. Increased OPN sputum levels have been detected in patients with COPD. Lung cancer (LC) and COPD are both smoking-related diseases and may share common pathogenetic mechanisms.Objective: We measured serum levels of OPN in patients with LC with and without coexistent COPD in order to evaluate its prognostic performance on 1-year mortality.Methods: We recruited 167 patients with LC, mean age 66±10 years, 119 current smokers, 85 with concomitant COPD, whereas 20 patients with COPD served as a control group. All subjects underwent lung function tests and serum collection for OPN measurement. All patients were optimally treated for LC and COPD according to their attending physicians and were followed for one year or until death.Results: Patients with LC (with or without concomitant COPD) presented higher serum OPN levels compared to those with COPD alone [median IQR 36 (23-54) vs 45 (24-69) vs 27(15-34) ng/ml respectively, p=0.006]. No significant difference was observed in serum OPN between the LC groups (with and without COPD, p=0.171). In multivariate Cox regression analysis, serum OPN > 50ng/ml was an independent predictor of 1-year mortality (HR 3.014 95% CI 1.821-5.130). SCLC was another significant predictor of 1-year mortality compared to NSCLC. (HR 1.19 95% CI 0.86-1.3).Conclusion: Serum OPN with a cut-off value of 50ng/ml could predict 1-year mortality in patients with lung cancer. The co-existence of COPD did not seem to affect its prognostic value.