TY - JOUR T1 - Renal denervation reduces pulmonary vascular remodeling in two experimental pulmonary arterial hypertension models JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2015.OA4997 VL - 46 IS - suppl 59 SP - OA4997 AU - Denielli Da Silva Goncalves Bos AU - Chris Happé AU - Ingrid Schalij AU - Wioletta Pijacka AU - Julian F. Paton AU - Harm-Jan Bogaard AU - Nico Westerhof AU - Albertus C. Van Rossum AU - Anton Vonk-Noordegraaf AU - Frances S. De Man AU - M. Louis Handoko Y1 - 2015/09/01 UR - http://erj.ersjournals.com/content/46/suppl_59/OA4997.abstract N2 - The aim of this study was to evaluate the effects of renal denervation on pulmonary vascular remodeling and cardiac function in two pulmonary artery hypertension (PAH) animal models.Methods: PAH was induced in male rats by a single injection of monocrotaline (60mg/kg; s.c.; MCT model; n=9/group) or by sugen 5416 (25mg/kg; s.c.) followed by 4 weeks of hypoxia (SuHx model; n=10/group). Before surgery, the development of PAH was confirmed by echocardiography. Rats were randomized for renal denervation or sham operation. At the end-of-study right ventricular (RV) pressure-volume measurement and histological analysis was performed on lung tissue.Results: Renal denervation was successful, confirmed by a reduction of kidneys norepinephrine content. In renal denervated rats, compared to sham, RV pressure-volume analysis showed significant reduction in: RV afterload (Figure 1A-1B) and RV end-diastolic elastance (12±2 vs. 22±3 MCT; 11±1 vs. 17±3 SuHx; mmHg/ml; p<0.01), whereas RV contractility remained unchanged. The extent of pulmonary vascular remodeling was significantly less in the renal denervated rats (Figure 1C-1D). Conclusion: Renal denervation reduces pulmonary vascular remodeling and RV afterload in both PAH experimental models. ER -