RT Journal Article SR Electronic T1 Efficacy of different treatment alternatives por obesity hypoventilation syndrome JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP OA1753 DO 10.1183/13993003.congress-2015.OA1753 VO 46 IS suppl 59 A1 Juan F. Masa A1 Jaime Corral A1 Maria L. Alonso A1 Estrella Ordax A1 Maria F. Troncoso A1 Mónica González A1 Soledad Lopez-Martínez A1 Jose M. Marin A1 Sergi Marti A1 Trinidad Díaz-Cambriles A1 Eusebi Chiner A1 Felipe Aizpuru A1 Carlos Egea YR 2015 UL http://erj.ersjournals.com/content/46/suppl_59/OA1753.abstract AB Rationale: Obesity hypoventilation syndrome (OHS) incidence may be increasing with the obesity epidemic. Despite extensive noninvasive ventilation (NIV) and continuous positive airway pressure (CPAP) use, information regarding efficacy is limited.Objectives: We performed a large multicenter randomized controlled study to determine the comparative efficacy of NIV, CPAP, and lifestyle modification (control group).Methods: Sequentially screened OHS patients with severe sleep apnea were randomized into the above-mentioned groups for a two-month follow-up. Arterial blood gases parameters, clinical symptoms, health-related quality-of-life assessments, polysomnography, spirometry, six-minute walk distance (6-MWD), dropouts, compliance, and side effects were evaluated. Statistical analysis was performed using intention-to-treat analysis, although adjustments for CPAP and NIV compliance were also analyzed.Results: 221 patients were randomized. NIV yielded the greatest improvement in PaCO2 and bicarbonate, with significant differences relative to the control. In the CPAP group, PaCO2 improvement was significantly different than in the control group only after CPAP compliance adjustment. Clinical symptoms and polysomnographic parameters improved similarly with NIV and CPAP relative to the control. However, the spirometry and 6-MWD results improved more with NIV than CPAP. Dropouts were similar between groups, and compliance and secondary effects were similar between NIV and CPAP.