%0 Journal Article %A Anderson Alves de Camargo %A Cristiane Helga Yamane de Oliveira %A Rodrigo Abensur Athanazio %A Samia Zahi Rached %A Rodolfo De Paula Vieira %A Alberto Cukier %A Rafael Stelmach %A Simone Dal Corso %T Is there a correlation between inflammatory status and exercise capacity in patients with bronchiectasis? Preliminary results %D 2015 %R 10.1183/13993003.congress-2015.PA2792 %J European Respiratory Journal %P PA2792 %V 46 %N suppl 59 %X Introduction: Patients with bronchiectasis present with higher levels of systemic inflammation that correlate with lung function, computed tomography scores, and quality of life. However, a possible association between systemic inflammation and exercise capacity and peripheral muscle strength (PMS) has not yet been investigated.Aim: To investigate the correlation between systemic pro- and anti-inflammatory cytokine levels with exercise capacity and PMS in patients with bronchiectasis.Methods: Twenty-six subjects (FEV1: 53±31%predicted, Age: 50±16yrs, BMI: 25±6kg/m2) were evaluated. The main exercise capacity outcomes were oxygen uptake (VO2, %predicted) and peak workload (%predicted), obtained from a maximum cardiopulmonary exercise test and the distance walked (%predicted) in the 6MWT. The main PMS outcomes were medium deltoideus (MD) and quadriceps femoris (QF) strength obtained through one-repetition maximum tests.Plasma concentrations of IL-1β, IL-6, IL-8, TNF-alpha, and IL-10 were measured by high sensitivity ELISA.Results: There were negative correlations between IL-1β and VO2 (r=-0.58, p=0.003) and peak workload (r=-0.49, p=0.011), but there was a trend for distance walked in the 6MWT (r=-0.35, p=0.082), IL-6 and MD strength (r=-0.44, p=0.02) and a trend toward correlation between IL-10 and QF strength (r=-0.34, p=0.09). There was no correlation among other cytokines and exercise capacity and PMS.Conclusion: As observed in other chronic lung diseases with systemic repercussions, it is reasonable to infer that inflammatory status is a cornerstone of reduced exercise capacity and peripheral muscle strength in patients with bronchiectasis. %U