RT Journal Article
SR Electronic
T1 Clinical and therapeutic characteristics of patients died due to radiation-induced pneumonitis
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA4835
DO 10.1183/13993003.congress-2015.PA4835
VO 46
IS suppl 59
A1 David Yabar
A1 Arturo Navarro
A1 Susana Padrones
A1 Ramón Palmero
A1 Jordi Dorca
A1 Samantha Aso
YR 2015
UL http://erj.ersjournals.com/content/46/suppl_59/PA4835.abstract
AB Introduction: The main limitation of radiotherapy (RT) in lung cancer treatment is the radiation-induced lung disease (RILD), with 15% of mortality. The aim to this study is to describe the clinical and therapeutic characteristics of patients died due to RILD and to identify possible factors that may be related to its mortality.Materials and Methods: Case-control study (2013-2014) with 28 patients who received radical chemo-radiotherapy. Cases included 14 patients died due to RILD. Clinical, therapeutic characteristics and pulmonary function were evaluated. The Radiation Theraphy Oncology Group (RTOG) scale was used for its severity.Results: Table nº1 shows demographic and clinical characteristics and pulmonary function . The table nº2 shows characteristics of the treatment .FeaturesControls (n=14)Cases (n=14)p valueAge (years)65,969,90,164Sex (M/F)11/312/20,621Smoking habit13 (92,9%)14 (100%)0,309Arterial hypertension4 (28,6%)8 (57,1%)0,127Diabetes Mellitus3 (21,4%)2 (14,3%)0,622FVC (mL)3134,330600,609FVC (%)89,687,40,767FEV1 (mL)2047,91953,60,467FEV1 (%)75,6730,572Demographic, clinical characteristics and pulmonary function of the 28 patientsFeaturesControls (n=14)Cases (n=14)p valueMean lung dose (Gy)13,818,50,012Maximun lung dose (Gy)67,362,20,061Total lung volume (mL)3451,33235,10,527V5 (%)51,162,50,038V20 (%)23,330,30,045RTOG (0-1)8 (61,5%)00,001RTOG (2-5)5 (38,5%)14 (100%)0,001Characteristics of the treatment of the 28 patientsConclusions: RILD mortality is associated with radiotherapy mean lung dose, V5, V20 and a RTOG score over 2. There was no statistical relevance in pulmonary function and cardiovascular risk factors.