RT Journal Article
SR Electronic
T1 Tracheal and bronchial granular cell tumours: A French retrospective study on 30 patients
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA4865
DO 10.1183/13993003.congress-2015.PA4865
VO 46
IS suppl 59
A1 Maxime Roger
A1 Samy Lachkar
A1 Mathieu Salaun
A1 Michel Febvre
A1 Jean Michel Vergnon
A1 Luc Thiberville
YR 2015
UL http://erj.ersjournals.com/content/46/suppl_59/PA4865.abstract
AB Introduction: Granular cell tumours (GCT, or Abrikossoff tumours) are rare, usually benign tumours, arising from Schwann cells. Tracheal and/or bronchial involvement has been rarely described.The objective of this study is to describe population characteristics, clinical and bronchoscopic data, as well as therapeutic options for bronchial or tracheal GCTs.Methods: All of the French cases of tracheal or bronchial GCT were included, and data were retrospectively collected.Results: Thirty-five cases of proximal GCT, including 10 tracheal and 25 bronchial lesions, in 30 patients were reported between 1994 and 2013. GCTs were more frequent in males (sex ratio = 1,5), the age at diagnosis was 48 y. (13–76 y.). Synchronous lung carcinoma was found in 3 patients (10%).Tumour diameter was higher in tracheal (23,8 mm) vs bronchial (9,8 mm) GCTs. The macroscopic aspect during bronchoscopy was usually a white, well-limited lesion without hypervascularization. Treatment information was not available for 7 patients. Seven other patients did not receive any treatment.Local treatment was performed in 12 patients, usually by mechanic resection combined with thermocoagulation. Complete endoscopic resection was obtained in 9/12 patients (75%). Surgery was performed in 4 patients (2 for suspected lung cancer ; one because of tracheal stenosis ; unavailable surgery indication for one patient), with complete resection. There was no recurrence of GCT during a median follow-up of 19 months.Conclusion: This is the largest series on proximal GCTs, which suggests that, when resection is needed, endoscopic treatment enables complete resection in most of the cases and appears as a reasonable first line treatment.