RT Journal Article
SR Electronic
T1 Influence of hospitalizations because of COPD exacerbation in the six-minute walk test (6MWT)
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA410
DO 10.1183/13993003.congress-2015.PA410
VO 46
IS suppl 59
A1 Amaia Aramburu
A1 Amaia Garcia
A1 Cristobal Esteban
A1 Ane Anton
A1 Francisco Javier Moraza
A1 Myriam Aburto
A1 Alberto Capelastegui
YR 2015
UL http://erj.ersjournals.com/content/46/suppl_59/PA410.abstract
AB Material and Methods: January 2003-2004, 543 patients with COPD (FEV1<80% and FEV1/FVC <70%) were selected. They had to be controlled by pneumologist for > 6 months and without exacerbations for at least the last six weeks. We evaluated different variables, including the number of exacerbations in the 2 years prior. They were monitored for 5 years without any intervention.A loss of 25m between the two evaluations was considered as a significant change.Results: Out of the 543 patients, 96% were male, of an average age of 68 years, BMI 28.3, 2.4±1.4 in Charlson index and FEV1 of 55.0±13.1%. 48.6% of the patients reported dyspnea grade 2 (MRC).The average distance covered (6MWT) was 408.9 ± 92.43m. 167 patients died during follow-up. At the inclusion, there were statistically significant differences (p<0.0001) in the distance achieved, 425±87 for those who had not suffered any hospitalization and 92.4±363 in those who did.After 5 years 324 patients completed the follow-up, 48.5 % of whom had lost at least 25m in the 6MWT. In the univariate analysis, there were statistically significant differences between the 2 groups in age, FEV1% and hospitalizations. There were no differences between groups for dyspnea, Charlson, BMI, general health and smoking. View this table:Multivariate analysisConclusion: There is an association between the number of exacerbations and the decrease of meters in 6MWT in our group after 5 years of follow-up.