RT Journal Article
SR Electronic
T1 Coronary artery calcification, epicardial fat burden, and cardiovascular events in COPD
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA3739
DO 10.1183/13993003.congress-2015.PA3739
VO 46
IS suppl 59
A1 Thomas Gaisl
A1 Christian Schlatzer
A1 Esther Schwarz
A1 Mathias Possner
A1 Julia Stehli
A1 Noriane Sievi
A1 Christian Clarenbach
A1 Damini Dey
A1 Piotr Piotr
A1 Philipp Kaufmann
A1 Malcolm Kohler
YR 2015
UL http://erj.ersjournals.com/content/46/suppl_59/PA3739.abstract
AB COPD patients suffer from more cardiovascular events than would be anticipated from conventional risk factors. The aim of this study was to determine whether COPD patients have a higher coronary artery calcium score (CACS) and epicardial fat burden, compared to control subjects, and their association with cardiovascular events.From a registry of 1906 patients 81 COPD patients were one-to-one matched to 81 non-COPD controls with a smoking history, according to their age, sex, and number of cardiovascular risk factors (arterial hypertension, diabetes mellitus, dyslipidemia, family history of premature coronary artery disease). CACS, epicardial fat, and major adverse cardiovascular events (MACE) during follow-up were compared between groups.Patients with COPD (GOLD I:5%, II:23%, III:16% and IV:56%) showed no difference in CACS (median difference +68 Agatston-Units p=0.899) or epicardial fat volume (mean difference -0.5 cm3, p=0.961) compared with controls. After a median follow-up of 42.6 months a higher incidence of MACE was observed in COPD patients (RR=2.80, p=0.016). Cox proportional hazard regression identified FEV1 and CACS as independent predictors for MACE.COPD patients experienced a higher MACE incidence compared to controls despite no baseline differences in CACS and epicardial fat. Other mechanisms such as undersupply of medication seem to account for an excess cardiovascular comorbidity in COPD.