TY - JOUR T1 - Atrial premature beats during the Mueller manoeuvre are a predictor for arrhythmias JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2015.PA2263 VL - 46 IS - suppl 59 SP - PA2263 AU - Thomas Gaisl AU - Annette Wons AU - Daniel Bratton AU - Christian Schlatzer AU - Esther Schwarz AU - Noriane Sievi AU - Christian Clarenbach AU - Laurent Haegeli AU - Firat Duru AU - Malcolm Kohler Y1 - 2015/09/01 UR - http://erj.ersjournals.com/content/46/suppl_59/PA2263.abstract N2 - Obstructive sleep apnoea (OSA) is associated with arrhythmias such as premature atrial beats (PABs) which can lead to paroxysmal atrial fibrillation and sudden cardiac death. The Mueller manoeuvre (MM) generates negative intrathoracic pressures similar to the ones observed during an obstructive apnoea. We tested the hypothesis whether PABs induced during a MM are associated with PABs recorded during a 24h-ECG and thus has the potential to be an indicator for the vulnerability of the heart.12-lead-electrocardiograms were recorded continuously in 40 patients with paroxysmal atrial fibrillation during a MM. All patients underwent nocturnal respiratory polygraphic measurements and 24h-ECG. Associations were determined using linear regression adjusted for potential confounders.According to the sleep study, 50% of patients (age: 60±10 years, 5 females) had OSA (apnoea hypopnoea index ≥5). Multivariable regression analysis showed that APBs during the MM were associated with the number of PABs in the 24h-ECG (r=0.51, p<0.001) independent of age, sex and body mass index. Obstructive apnoeas during the sleep study were more often observed in patients with PABs during the MM when compared with patients without PABs during the MM (p=0.013) independent of age, sex and body mass index.PABs during the Mueller Manoeuvre seem to be a predictor for the spontaneous occurrence of PABs during night- and daytime. Patients with OSA seem to be especially vulnerable to cardiac arrhythmias such as PABs. ER -