RT Journal Article SR Electronic T1 LATE-BREAKING ABSTRACT: Who benefits most from COPD self-management interventions? An individual patient data meta-analysis JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP PA1804 DO 10.1183/13993003.congress-2015.PA1804 VO 46 IS suppl 59 A1 Nini Jonkman A1 Heleen Westland A1 Jaap Trappenburg A1 Rolf Groenwold A1 Erik Bischoff A1 Jean Bourbeau A1 Christine Bucknall A1 David Coultas A1 Tanja Effing A1 Michael Epton A1 Frode Gallefoss A1 Judith Garcia-Aymerich A1 Suzanne Lloyd A1 Evelyn Monninkhof A1 Huong Nguyen A1 Job van der Palen A1 Kathryn Rice A1 Maria Sedeno A1 Stephanie Taylor A1 Thierry Troosters A1 Nicholas Zwar A1 Arno Hoes A1 Marieke Schuurmans YR 2015 UL http://erj.ersjournals.com/content/46/suppl_59/PA1804.abstract AB Background: Self-management interventions are considered effective in COPD patients, but trials have shown inconsistent results and it is unknown which patients benefit most.Aims: To summarise the evidence on effectiveness of self-management interventions and identify subgroups of COPD patients who benefit most.Methods: Randomised trials on self-management interventions between 1985 and 2013 were identified through a systematic literature search. The original data of selected studies were analysed using generalised mixed effects models.Results: Fourteen trials representing 3282 patients were included. Self-management improved health-related quality of life (standardised mean difference 0.08, 95%CI 0.00-0.16), COPD-related hospitalisation (hazard ratio 0.79, 95%CI 0.66-0.94) and all-cause hospitalisation (hazard ratio 0.80, 95%CI 0.69-0.90), but had no effect on mortality. Pre-specified subgroup analysis showed significant interactions for certain outcomes: interventions were more effective in males (6-month COPD-related hospitalisation: P=0.006), patients with severe lung function (6-month all-cause hospitalisation: P=0.016), moderate self-efficacy (12-month COPD-related hospitalisation: P=0.036), and high body mass index (6-month-COPD-related hospitalisation: P=0.028; and 6-month mortality: P=0.026).Conclusion: Self-management improved health-related quality of life, COPD-related and all-cause hospitalisation in COPD patients. Our findings support implementation of self-management strategies in practice and suggest subgroups with greater benefit. However, the inconsistent subgroup effects across outcomes do not endorse targeting to subgroups at this stage of our understanding.