RT Journal Article
SR Electronic
T1 The role of cytomegalovirus in the development of bronchiolitis obliterans syndrome
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA1802
DO 10.1183/13993003.congress-2015.PA1802
VO 46
IS suppl 59
A1 Ildar Zinnatullin
A1 Elena Orlova
A1 Alisa Volkova
A1 Sergey Bondarenko
A1 Andrey Kozlov
A1 Vladimir Vavilov
A1 Olga Slesarchuk
A1 Alexander Kulagin
A1 Ildar Barkhatov
A1 Alexei Chukhlovin
A1 Ludmila Zubarovskaya
A1 Boris Afanasyev
YR 2015
UL http://erj.ersjournals.com/content/46/suppl_59/PA1802.abstract
AB Introduction: Cytomegalovirus (CMV) infection is a well-studied complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). It remains one of the causes of graft- versus-host disease (GVHD), despite widespread prevention and treatment.Aims and objectives: To define the role of CMV infection in the development of bronchiolitis obliterans syndrome (BOS).Methods: Our group examined 1142 patients after allo-HSCT between 2012 - 2014. Pulmonary function test (PFT) was performed in all patients. Patients with BOS underwent high-resolution computer tomography (HRCT), bronchoscopy with complex microbiological diagnostics of bronchoalveolar lavage (BAL), control of CMV replication in blood, BAL and urine; 4 patients underwent videothoracoscopic lung biopsy with histological examination.Results: BOS was diagnosed in 24 (2%) patients between 4 and 14 months after allo-HSCT. Male/female – 10/14, 16 - 56 years old; OLL - 10, OML - 7, HL - 4, CLL - 1, MDS - 1, MM - 1; conditioning regimen – myeloablative/nonmyeloablative – 13/11. Allo-HSCT from related donor were performed in 5 patients, unrelated - 17, haplo - 2. In patients with BOS in the first 100 days after allo-HSCT, CMV was detected in blood in 15 cases, in BAL – 2, in urine - 1, 6 patients had no CMV reactivation. Persistent obstructive interruptions on PFT (FEV1 < 80%), mosaic perfusion and bronchial wall thickening on HRCT and no signs of active infection have been detected in all patients during the observation.Conclusions: Patients after allo-HSCT are susceptible to CMV infection, especially, in the first 100 days. CMV infection can provoke the development of BOS in the period between 4 and 14 months.