TY - JOUR T1 - Scoring system predicting for elevation of MPAP in IPF JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2015.OA4961 VL - 46 IS - suppl 59 SP - OA4961 AU - Taiki Furukawa AU - Hiroyuki Taniguchi AU - Yasuhiro Kondoh AU - Tomoki Kimura AU - Kensuke Kataoka AU - Toshiaki Matsuda AU - Toshiki Yokoyama AU - Mitsuaki Yagi Y1 - 2015/09/01 UR - http://erj.ersjournals.com/content/46/suppl_59/OA4961.abstract N2 - Background: Borderline pulmonary hypertension (PH, 21 ≤ mean pulmonary arterial pressure (MPAP) ≤ 24mmHg) is frequently seen in idiopathic pulmonary fibrosis (IPF) and has a significant adverse impact on survival as well as PH (MPAP ≥ 25mmHg). Therefore, early diagnosis of MPAP ≥ 21 mmHg is crucial for patients with IPF.Objective: The aim of this study was to predict elevation of MPAP (MPAP ≥ 21mmHg) in IPF by using combination of non-invasive examinations.Method: We retrospectively analyzed the consecutive patients with IPF who underwent multidimensional initial evaluation and right heart catheterization from June 2007 to June 2012 in our hospital. The diagnosis of IPF was made according to the 2011 international guideline for IPF. We used a Cox proportional hazards model to identify independent predictors for elevation of MPAP.Result: 200 cases (male 169, surgical lung biopsy 99) with mean age of 65.6 years old were studied. At the time of initial evaluation, 44 cases fulfilled the criteria of elevation of MPAP. Multivariate models demonstrated %DLco < 50 % [odds ratio (OR) 3.7, (95% CI 1.8-8.8)], PA/Ao ratio on HRCT scan > 0.9 [OR 4.0 (1.7-8.0)], and modified MRC (mMRC) ≥ 2 [OR 4.4 (2.0-9.6)] were independent predictors for elevation of MPAP. When we assigned a single point to each variables, elevation of MPAP was 4.4 % in the 0-point group, 12.1 % in 1-point, 48.9 % in 2-point, and 66.7 % in 3-point. The value of the area under the ROC curve of this model was 0.82 (0.75-0.89). The Beta value of Bootstrapped validation was similar to the original beta value.Conclusion: A simple clinical scoring system consisting of %DLco, PA/Ao ratio on HRCT scan, and mMRC could predict elevation of MPAP in our cohort of patients with IPF. ER -