TY - JOUR T1 - Are serum leptin levels a prognostic factor in advanced lung cancer? JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2015.PA4245 VL - 46 IS - suppl 59 SP - PA4245 AU - Ceyda Anar AU - Derya Deniz AU - Serhat Erol AU - Yasemin Ozdogan AU - Melike Yuksel Yavuz AU - Ufuk Yilmaz AU - Huseyin Halilcolar Y1 - 2015/09/01 UR - http://erj.ersjournals.com/content/46/suppl_59/PA4245.abstract N2 - Introduction: There is need for reliable prognostic factors for advanced lung cancer.Aim: To evaluate pre-treatment concentration of leptin with clinicopathological variables, response to therapy and overall survival in patients with advanced lung cancer.Methods: There are 71 untreated patients with primary lung cancer. Weight and height were recorded at admittance and BMI (body mass index) was calculated. Forty five healthy individuals', age, sex and BMI matched to the lung cancer patients, were recruited as control group. Leptin levels were measured by a microELISA kit.Results: The serum leptin levels at diagnosis were significantly lower in lung cancer patients than in control group (4.75 ±4.91 ng/ml, 9.67 ± 8.02 ng/ml; p< 0,002). We didn't find any significant difference in leptin values related to clinicopathological parameters such as ECOG, weight loss, histological type, disease stage and TNM classification. But there was a statistically significant difference between leptin levels and BMI and age. We demonstrated significant correlation between serum leptin levels and BMI of lung cancer patients (Correlation coefficient: 0,303; p>0,010). Serum leptin values didn't show any association with the overall survival of the patients. Stage, ECOG, response to the treatment were proved as additional independent factors for the overall survival of lung cancer patients in our study (p=0.027, 0.013, 0.001 respectively).Conclusion: Our results showed that serum leptin levels of lung cancer patients were significantly lower compared to healthy control. Furthermore, leptin was correlated with BMI, but not correlated with other factors. Current results suggest that leptin might not be independent prognostic factor for survival. ER -