@article {SheikhPA3736, author = {Shahid Sheikh and Brian Handly and Nancy Ryan-Wenger and Steve Kirkby and Chandar Ramanathan and Karen McCoy and Don Hayes, Jr. and Meredith Lind}, title = {LATE-BREAKING ABSTRACT: A new, easy to use computed tomography based scoring system for sinus disease in cystic fibrosis: Validated with acceptable inter- and intra-rater reliability}, volume = {46}, number = {suppl 59}, elocation-id = {PA3736}, year = {2015}, doi = {10.1183/13993003.congress-2015.PA3736}, publisher = {European Respiratory Society}, abstract = {Background: There is no CF specific CT based scoring system for sinus disease in CF.Aim/Objective: We propose a scoring system to quantify severity of CF related sinus disease.Design/Methods: After IRB approval, we validated a scoring system in 197 patients with CF ages 8-30 years (mean 17{\textpm}6.3) and 120 aged matched non CF controls. CT were blindly interpreted by a pulmonologist, otolaryngologist, and a neuro-radiologist twice. Parameters:maxillary opacification and nasal cavity obstruction scored on an ordinal level (0-3) with 0=normal, 1=mild (\<33\%), 2=moderate (33-66\%) and 3=severe (\>66\%), while nasal wall displacement, Uncinate process absent/demineralized, and Mucocele were scored as 1=yes, 0=no. Intra-rater and inter-rater reliability was measured using criteria derived from Landis \& Koch (1997):0.0-0.2= poor, 0.21-0.4=fair, 0.4-0.6=moderate, 0.61-0.8=strong, and 0.81-1.0=excellent agreement.Results: Intra-Rater Reliability: In CF cohort, reliability for the 10 CT categories across the three raters ranged 33\%-100\%. Two (6.6\%) were moderate and 27 (90\%) were strong to excellent reliabilities. In control group, 2 (6.6\%) were strong and 28 (93.3\%) were excellent. Inter-Rater Reliability: in CF cohort, 10 CT categories across the three raters ranged from 10\%-92\%. Strong-excellent reliability (>=60\%) were noted in 11 (36.3\%), moderate in 7 (23.3\%), fair in 11 (36.3\%) and poor in 1 (3\%). In control group, 4 (13.3\%) were moderate, 2 (6.6\%) strong and remaining 24 (80\%) excellent.Conclusion: A new easy to use CT based scoring system for CF sinus disease was validated with acceptable inter- and intra-rater reliability.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/46/suppl_59/PA3736}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }