RT Journal Article SR Electronic T1 Analysis of factors affecting pretransplant pulmonary function tests and impact on overall survival after allogenic stem cell transplantation JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP PA4544 DO 10.1183/13993003.congress-2015.PA4544 VO 46 IS suppl 59 A1 Fátima Díaz-Chantar A1 Jose Antonio Rodríguez-Portal A1 Rocío Parody A1 Oriana López A1 Nancy Rodríguez YR 2015 UL http://erj.ersjournals.com/content/46/suppl_59/PA4544.abstract AB Intro: Basal value of diffusing capacity of the lung for transferring carbon monoxide (DLCOc corrected by hemoglobin) is a well recognized impact factor for non-relapse mortality in stem cell transplantation(SCT),and a relative contraindication for values<50%.Around 40-50% of patients have a DLCOc<80% pretransplantMaterials & methods: We designed a retrospective and multicenter study with 365 patients undergoing to allogeneic SCT (alloSCT) in the last 5 years,to analyze the impact of preSCT variables on DLCOc,such as age,sex,basal disease,status at transplant,time from diagnosis to alloHSC,prior pulmonary infections,non-infectious complications and different previous treatmentsResults: In univariate analysis significant factors for DLCO<80% were age,female sex,prior radiotherapy and prior non-infectious lung disease.In multivariate analysis the factors remained statistically significant for decreasing DLCOc were female sex,smoking,and a trend was found for prior SCT and previous non-infectious lung disease.Overall survival was significantly lower for patients with preSCT DLCOc<80% with respect to DLCOc >80% Conclusion: Low pretransplant DLCOc has a significant impact on overall survival after alloSCT.Among the variables which significantly influenced on DLCOc,prior treatment should be closely monitored