RT Journal Article
SR Electronic
T1 Ratio of pulmonary arterial to aortic diameter and right to left ventricular diameter associate with poor outcome in medically-treated chronic thromboembolic pulmonary hypertension
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA3747
DO 10.1183/13993003.congress-2015.PA3747
VO 46
IS suppl 59
A1 Ryogo Ema
A1 Toshihiko Sugiura
A1 Naoko Kawata
A1 Rintaro Nishimura
A1 Takayuki Jujo
A1 Ayako Shigeta
A1 Seiichiro Sakao
A1 Nobuhiro Tanabe
A1 Koichiro Tatsumi
YR 2015
UL http://erj.ersjournals.com/content/46/suppl_59/PA3747.abstract
AB Background: The dilatation of pulmonary artery (PA) and right ventricle (RV) on chest CT are often observed in clinical practice of pulmonary hypertension. The clinical meanings of these signs have not been clearly explained in patients with chronic thromboembolic pulmonary hypertension (CTEPH). So, we investigate whether these signs at the diagnosis correlate the poor outcome.Methods: This study was a retrospective cohort investigation of 60 subjects with inoperable CTEPH diagnosed consecutively between 1997 and 2010 at Chiba University Hospital. Digital scout CT images of the chest were obtained with a multi-detector CT scanner. At the mediastinal window setting of the axial images, the main PA/AA ratio was calculated as the ratio of main pulmonary arterial to ascending aortic diameter, and RV/LV ratio as the ratio of right to left ventricular diameter. Outcome was obtained from hospital chart reviews, and telephone interviews with the referring physician.Results: Main PA/AA ratio ranged from 0.85 to 1.84 (mean, 1.15±0.23), and RV/LV ratio ranged from 0.71 to 2.88 (mean, 1.34±0.53). During a median follow-up of 1284.5 days (range, 21 to 4550days), 14 patients got worse and hospitalized. Among them, 6 patients died. Kaplan-Meier analysis showed definite differences in hospitalization between patients with main PA/AA ratio≥1.1 and those with main PA/AA ratio<1.1(Log-rank test, P=0.014), and between RV/LV ratio≥1.2 and those with RV/LV ratio<1.2 (Log-rank test, P=0.013).Conclusions: Main PA/AA ratio and RV/LV ratio by contrast CT were associated with poor outcome in medically-treated CTEPH.