RT Journal Article
SR Electronic
T1 Systemic inflammation, comorbidities and the outcome of adult-onset asthma
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA1077
DO 10.1183/13993003.congress-2015.PA1077
VO 46
IS suppl 59
A1 Ilmarinen, Pinja
A1 Tuomisto, Leena E.
A1 Niemelä, Onni
A1 Danielsson, Joanna
A1 Haanpää, Jussi
A1 Kankaanranta, Hannu
YR 2015
UL https://publications.ersnet.org//content/46/suppl_59/PA1077.abstract
AB Background: Systemic inflammation, characterized by elevated IL-6, has been associated with chronic respiratory diseases and cardiovascular, psychiatric and rheumatic disorders. However, its role in patients with adult-onset asthma with and without comorbidities is unclear.Aims and Objectives: To compare lung function and levels of IL-6 in patients with adult-onset asthma with and without comorbidities.Methods: Seinäjoki Adult Asthma Study (SAAS) is a 12-year follow-up of patients (n=203) with new-onset asthma diagnosed at adult age. Clinical information on comorbidities and medication were collected from all participants. Lung function was measured at baseline and follow-up. Serum levels of IL-6 were determined by ELISA.Results: In this material, 110 (54 %) suffered from at least one of the following comorbidities: diabetes, hypertonia, coronary heart disease, hypercholesterolemia, psychiatric disorder, COPD or systemic rheumatic disease (selected comorbid group). Thirty six patients (18 %) suffering from other comorbid condition(s) such as non-specific musculoskeletal disorders were excluded. Fifty seven patients (28 %) showed no other disease in addition to asthma/asthma-related conditions. In comparison to patients with no comorbidities, patients with selected comorbidities showed elevated levels of IL-6, lower lung function, higher AQ20 score and higher proportion of uncontrolled asthma despite higher daily dose of ICS. IL-6 level was positively associated with the number of selected comorbidities and showed a negative correlation to post-bronchodilator FEV1 (R=-0,338, p<0,01).Conclusions: Comorbidities and elevated IL-6 levels may play a role in poor outcome of patients with adult-onset asthma.