RT Journal Article
SR Electronic
T1 The REVIVE study: A randomised controlled trial of the effect of a programme of exercise on physical function in survivors of critical illness after discharge from the intensive care unit
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP OA274
DO 10.1183/13993003.congress-2015.OA274
VO 46
IS suppl 59
A1 McDowell, Kathryn
A1 O'Neill, Brenda
A1 Blackwood, Bronagh
A1 Clarke, Chris
A1 Gardner, Evie
A1 Johnston, Paul
A1 Kelly, Michaeline
A1 McCaffrey, John
A1 Mullan, Brian
A1 Murphy, Sally
A1 Trinder, John
A1 Lavery, Gavin
A1 McAuley, Daniel F.
A1 Bradley, Judy M.
YR 2015
UL http://erj.ersjournals.com/content/46/suppl_59/OA274.abstract
AB Aim: To investigate the effectiveness of a 6-week programme of exercise in patients discharged from hospital after critical illness compared to standard care.Methods: Multicentre phase 2 RCT of exercise versus standard care. Inclusion criteria:≥18 yrs, mechanical ventilation>96 hrs, no other rehabilitation programme. Primary outcome: physical functioning subscale(PF) of Short-Form-36(SF-36). Secondary outcomes: other SF-36 subscales, Incremental Shuttle Walk Test(ISWT), Functional Limitations Profile(FLP), Chronic Disease Self-efficacy Scale(CDSES), readiness to change(RTC), Hospital Anxiety and Depression(HADS), Rivermead Mobility Index(RMI). Data analysis:differences between groups using independent samples t-tests and analysis of covariance(p ≤0.05=significant).Results: 60 patients (30 per group); age 51(14)yrs; 34(57%)male; APACHE2 16(7); mechanical ventilation 303(251)hrs. 6 week follow-up completed by n=55 (29control, 26 intervention). Preliminary results:no significant difference in PF between groups at 6 weeks; significant differences in SF-36 role physical(RP), ISWT, FLP, CDSES and RTC in favour of exercise group. Conclusion: This is the first study of exercise rehabilitation initiated after discharge from hospital following critical illness to demonstrate significant improvements in functional outcomes and self-efficacy.