PT  - JOURNAL ARTICLE
AU  - McDowell, Kathryn
AU  - O'Neill, Brenda
AU  - Blackwood, Bronagh
AU  - Clarke, Chris
AU  - Gardner, Evie
AU  - Johnston, Paul
AU  - Kelly, Michaeline
AU  - McCaffrey, John
AU  - Mullan, Brian
AU  - Murphy, Sally
AU  - Trinder, John
AU  - Lavery, Gavin
AU  - McAuley, Daniel F.
AU  - Bradley, Judy M.
TI  - The REVIVE study: A randomised controlled trial of the effect of a programme of exercise on physical function in survivors of critical illness after discharge from the intensive care unit
AID  - 10.1183/13993003.congress-2015.OA274
DP  - 2015 Sep 01
TA  - European Respiratory Journal
PG  - OA274
VI  - 46
IP  - suppl 59
4099  - http://erj.ersjournals.com/content/46/suppl_59/OA274.short
4100  - http://erj.ersjournals.com/content/46/suppl_59/OA274.full
SO  - Eur Respir J2015 Sep 01; 46
AB  - Aim: To investigate the effectiveness of a 6-week programme of exercise in patients discharged from hospital after critical illness compared to standard care.Methods: Multicentre phase 2 RCT of exercise versus standard care. Inclusion criteria:≥18 yrs, mechanical ventilation>96 hrs, no other rehabilitation programme. Primary outcome: physical functioning subscale(PF) of Short-Form-36(SF-36). Secondary outcomes: other SF-36 subscales, Incremental Shuttle Walk Test(ISWT), Functional Limitations Profile(FLP), Chronic Disease Self-efficacy Scale(CDSES), readiness to change(RTC), Hospital Anxiety and Depression(HADS), Rivermead Mobility Index(RMI). Data analysis:differences between groups using independent samples t-tests and analysis of covariance(p ≤0.05=significant).Results: 60 patients (30 per group); age 51(14)yrs; 34(57%)male; APACHE2 16(7); mechanical ventilation 303(251)hrs. 6 week follow-up completed by n=55 (29control, 26 intervention). Preliminary results:no significant difference in PF between groups at 6 weeks; significant differences in SF-36 role physical(RP), ISWT, FLP, CDSES and RTC in favour of exercise group. Conclusion: This is the first study of exercise rehabilitation initiated after discharge from hospital following critical illness to demonstrate significant improvements in functional outcomes and self-efficacy.