RT Journal Article
SR Electronic
T1 Prevalence and underdiagnosis of COPD in patients with ischemic heart disease demonstrated by coronary angiography. Prognostic implications
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA4807
DO 10.1183/13993003.congress-2015.PA4807
VO 46
IS suppl 59
A1 Annie Navarro
A1 Ana Maria Lapuente
A1 Julia Pareja
A1 Angela Barrera
A1 Sergi Yun
A1 Alejandro De La Sierra
A1 Jose Luis Heredia
A1 Pere Almagro
YR 2015
UL http://erj.ersjournals.com/content/46/suppl_59/PA4807.abstract
AB Introduction: Retrospective studies based on clinical data and without spirometric confirmation suggest a poor prognosis of patients with ischemic heart disease (IHD) and chronic obstructive pulmonary disease (COPD) following percutaneous coronary intervention (PCI). Impact of undiagnosed COPD in these patients is unknown. The aim of our study was to evaluate the prevalence of COPD in patients with IHD treated with PCI, and prognosis impact of COPD –previously or newly diagnosed- in these patients.Material and Methods: Patients with IHD confirmed by PCI were consecutively included. After PCI, the pacients underwent forced spirometry and evaluation of cardiovascular risk factors. Mortality, new cardiovascular events, and their combined endpoint were analyzed.Results: A total of 133 patients (78% male), with a mean (SD) age of 63 (10.12) years were included. Out of the whole group, 33 (24.8%) met the spirometric criteria for COPD, of which 81.8% were undiagnosed. IHD patients with COPD were older, had more coronary vessels affected and a greater history of previous IHD. Median follow-up was 934 days (IQR 25-75%: 546-1160). COPD patients had greater mortality (p=0.008; H.R. 8.85; CI 95%:1.76-44.47) and number of cardiovascular events (p=0.024; H.R. 1.87; CI 95%: 1.04-3.33), even those without a previous diagnosis of COPD (p=0.01; H.R.: 1.78; CI 95%: 1.12-2.83). These differences remained after adjustment for possible confounding variables.Conclusions: Prevalence and underdiagnosis of COPD in patients with IHD who undergo PCI are both high. These patients showed greater mortality and a higher number of cardiovascular events during follow-up.