TY - JOUR T1 - Effectiveness of tuberculosis detection using a skin test with allergen recombinant (CFP-10-ESAT-6) in children JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2015.PA4524 VL - 46 IS - suppl 59 SP - PA4524 AU - L. Slogotskaya AU - E. Bogorodskaya AU - O. Sentchichina AU - D. Ivanova AU - G. Nikitina AU - V. Litvinov AU - P. Seltsovsky AU - D. Kudlay AU - N. Nikolenko AU - S. Borisov Y1 - 2015/09/01 UR - http://erj.ersjournals.com/content/46/suppl_59/PA4524.abstract N2 - Aim: To determine the efficiency of recombinant proteins CFP10-ESAT6 (DST) for screening for tuberculosis (TB) in children and adolescents.Methods: During 2014 inMoscow the Mantoux test with 2 TU PPD-L was performed in 1429395 children and adolescents (97,3% of all children and adolescents), positive reactions were observed in 1058191 individuals (74.0%), among them DST was performed in 88527 (8,4%). All children with positive DST-reactions were performed computer tomography - it was possible to diagnose light forms of TB.Results: Among 88527Mantoux-positive who were examined by the DSTpositive reactions were observed in 3573 cases (4.0%).Among DST-positive new cases of TB were identified in 147 persons (4.1% 95%CI 3.43-4.79),including2 childrenwith HIV infection. Among 88527Mantoux-positive new cases of TB were identified in 0.17%(95%CI 0.14-0.19). Detection rate was 24 times lower compared to positive DST, p=0,000. In 2014 in Moscow number of TB new cases was 166. Among them 151 were examined by the DST and positive DST-reactions were observed in 147 (97.4% 95%CI94.14-100.0%). Negative DST reactions were observed: in2 children who had BCG-ostitis; in 1 child with pleurisyand 1 case of peripheral lymph nodesTB incalcination stage. Among newTB cases, 75.7% were "minor" TB forms.Conclusion: DST demonstrated its high efficiency - detection rate in individuals with positive DST was 24-time higher compared to positive Mantoux test. High sensitivity (97.4%) allows to detect the vast number of TB.Positive DST reaction is the criteria for additional examination using of computed tomography, that allows to detect minor TB forms. ER -