%0 Journal Article %A David Araújo %A Leonor Meira %A Leonor Almeida %A Rita Boaventura %A Nuno Osório %A Ivo Ferreira %A Sara Magalhães %A Angélica Ramos %A Teresa Carvalho %A Fernando Rodrigues %A António Castro %A João Tiago Guimarães %A Margarida Saraiva %A Helder Novais Bastos %T HIV and tuberculosis co-infection: A 7 year retrospective cohort study %D 2015 %R 10.1183/13993003.congress-2015.PA2728 %J European Respiratory Journal %P PA2728 %V 46 %N suppl 59 %X Introduction: Of the estimated 9 million new cases of tuberculosis (TB) each year, 1.1 million are co-infected with HIV. This infection plays an important role in TB, with major clinical impact.Aims: Compare the differences between HIV and non-HIV co-infected TB patients.Methods: A retrospective analysis was made of all the patients diagnosed with TB during a period of 7 years at Centro Hospitalar de São João. Demographic, clinical, analytical and radiological characteristics were assessed.Results: Out of a total of 714 patients with TB diagnosis, 470 patients met the inclusion criteria (age ≥18 years, HIV serology tested). A total of 105 (20.3%) patients were HIV+. The age at diagnosis was significantly lower at the HIV+ group (43.0±13.2 vs 51.9±18.7; p<0,05). This group showed less frequently haemoptysis (8.4% vs 19.1% , p<0,05) and more fever (75.0% vs 59.6%, p<0,05) and hypersudoresis (61.6% vs 45.5%, p<0,05). Extra-pulmonary TB was more frequent in the HIV+ group (58.7% vs 29.2%, p<0,05) as well as disseminated TB (48.1% vs 9.5%, p<0,05) and milliary TB (16.8% vs 4.1%, p<0.05). Pleural TB was less frequent however (6.7% vs 13.9%, p<0,05). There was a smaller proportion of cavitary disease (32.5% vs 52.9%, p<0,05) and parenchymal consolidation (52.2% vs 83.4%, p<0,05) in HIV+ patients. In terms of radiological severity, HIV+ patients presented a milder extent disease (p<0,05).Conclusions: The patients with HIV co-infection have a set of significant clinical, analytical, radiological and diagnostic particularities. HIV infection poses as risk for the development of extrapulmonary and disseminated TB. %U