RT Journal Article SR Electronic T1 LATE-BREAKING ABSTRACT: Differences in S. pneumoniae serotypes distribution causing CAP in hospitalized adults in Spain according to comorbidities by a new urinary antigen detection (UAD) test. The CAPA study JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP PA2581 DO 10.1183/13993003.congress-2015.PA2581 VO 46 IS suppl 59 A1 Rosario Menéndez A1 Antoni Torres A1 Pedro Pablo España A1 Emilio Pérez-Trallero A1 José Luis López Hontangas A1 Francesc Marco A1 Ana Patricia Martínez de la Fuente A1 José María Marimón A1 Alexandra Gimeno A1 Catia Cilloniz A1 Ane Uranga A1 María Ercibengoa A1 César Balseiro A1 Cristina Méndez A1 Isabel Cifuentes YR 2015 UL http://erj.ersjournals.com/content/46/suppl_59/PA2581.abstract AB Background and objective: The presence of underlying conditions increases the risk of CAP. The 13-valent pneumococcal conjugate vaccine (PCV13) has demonstrated efficacy in the prevention of pneumococcal pneumonia and invasive pneumococcal disease in adults. In order to assess the burden of CAP, including non-bacteremic CAP, due to PCV13 serotypes (St), we explored differences in the distribution of PCV13 St in immunocompetent patients >18 years hospitalized in 3 Spanish hospitals (November 2011-June 2014) by presence of underlying conditions.Methods: In subjects hospitalized with chest X-ray confirmed CAP, microbiological confirmation was sought by the novel UAD assay (Pfizer's PCV13 serotype specific urinary antigen detection test), BinaxNOW & conventional cultures. Serotyping of pneumococcal isolates was accomplished in a central laboratory using Quellung reaction.Results: S. pneumoniae CAP was confirmed in 351 (29.8%) of 1179 included patients. Underlying conditions and/or risk habits were present in 87.4% of patients (mean age 67.7±17.9). Below table shows PCV13 St distribution in CAP by presence of specific underlying conditions according to UAD test results. Conclusion: Among at risk adults with chronic diseases, more than 50% of pneumococcal CAP cases were due to PCV13 serotypes.