PT - JOURNAL ARTICLE AU - Francesco Costa AU - Dario Nieri AU - Maria Laura Bartoli AU - Sandra Antonelli AU - Gianna Decusatis AU - Claudia De Simone AU - Laura Malagrinò AU - Sabrina Santerini AU - Barbara Vagaggini AU - Pierluigi Paggiaro TI - Determinants of cardio-pulmonary exercise test (CPET) and shuttle walking test (SWT) in COPD patients are different AID - 10.1183/13993003.congress-2015.PA2209 DP - 2015 Sep 01 TA - European Respiratory Journal PG - PA2209 VI - 46 IP - suppl 59 4099 - http://erj.ersjournals.com/content/46/suppl_59/PA2209.short 4100 - http://erj.ersjournals.com/content/46/suppl_59/PA2209.full SO - Eur Respir J2015 Sep 01; 46 AB - Aim: Physiologic and biologic determinants of exercise tolerance in COPD have not been extensively studied.Methods: We examined 45 COPD patients (36 male, age 69.9±7.1 yrs, pack-yrs 50.8±28.2, FEV1 52.5±17.0 %pred) attending to a pulmonary rehabilitation program. All of them underwent a detailed functional (including static lung function, diffusing capacity, MIP, MEP) and biologic (blood and sputum inflammatory cells, blood haemoglobin, CRP and pro-BNP) evaluation. Exercise capacity was assessed by incremental CPET on cycloergometer (VO2peak/kg: 17.5±5.5 ml/min/kg) and by incremental SWT (284.4±128.0 m) (dependent variables). Several independent variables were considered for predicting VO2peak/kg or SWT. Multivariate analysis was performed including all independent variables which were significantly correlated to the dependent variables.Results: FEV1, IC, DLco, blood hemoglobin and pro-BNP were all significantly correlatd with VO2peak/kg and SWT, but age and MIP/MEP significantly correlated only with SWT. In a logistic regression analysis, blood hemoglobin tended to be significantly correlated with VO2peak/kg (p=0.08, r2: 0.23), while hemoblobin, MIP and age significantly correlated with SWT (p<0.001 for each variables, cumulative r2: 0.63).Conclusion: The difference in the main determinants of CPET and SWT suggests that these two tests for assessing exercise capacity are exploring different physiologic and biologic features of COPD.