TY - JOUR T1 - Impact of gastrostomy insertion in CF population on lung function JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2015.PA1310 VL - 46 IS - suppl 59 SP - PA1310 AU - Rania Abusamra AU - Leo Thanikkel AU - Hannah Fox AU - Robert Ross-Russell Y1 - 2015/09/01 UR - http://erj.ersjournals.com/content/46/suppl_59/PA1310.abstract N2 - Objectives: The positive impact of optimal nutritional status and increasing BMI on clinical outcome including lung function in cystic fibrosis is established.Do BMI and lung function improve with gastrostomy insertion? Evidence so far has been ambiguous.The aim of this study was to measure changes in BMI,BMI z score and lung function (FEV1 percentile predicted and FVC percentile predicted) pre and post gastrostomy in CF patients.We further assessed the number of days of IV antibiotics required pre and post gastrostomy.Methods: Data of 10340 patients was obtained from the UK CF trust database (2007-2013).Extraction was limited to 163 paediatric and adult patients that had gastrostomy with available data 2 years pre and post gastrostomy.Data was analysed using SPSS. Conclusion: Both parametric and non-parametric are performed to the data for comparison.They reveal similar conclusion that there is indeed a significant difference in BMI,BMIz-score,FEV1,FVC,and total IV days between pre and post gastrostomy at 5% level.BMI for adult patients was higher by 0.769 after gastrostomy inserted.It was also the same for younger patients, there was an increase by 0.254 in BMI z-score after gastrostomy.FEV1 and FVC percentile predicted were decreasing by -6.448 and -6.262,respectively.Also there was a significant increase for total days of IV antibiotics required after gastrostomy inserted.Further studies to compare the gastrostomy group to controls are underway. ER -