TY - JOUR T1 - First in class, respiratory drug gas & drug vapor delivered in a revolutionary and new portable device JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2015.PA4035 VL - 46 IS - suppl 59 SP - PA4035 AU - John Dennis AU - Andy Clark AU - Ian McAffer AU - Stefan Dalberg AU - Francis Green Y1 - 2015/09/01 UR - http://erj.ersjournals.com/content/46/suppl_59/PA4035.abstract N2 - Our drug-gas containing 8% CO2 in air combined with perfluorooctylbromide (Perflubron) vapor is being developed as a new class of fast acting bronchodilator drug working via unique biophysical mechanisms.The revolutionary portable delivery device incorporates separate storage of a compressed gas cylinder and a drug-liquid ampoule within the device body. On activation, compressed drug-gas is released through the liquid reservoir where perflubron vapor evaporates through an intermediate aerosol stage. The combined gas and vapor mixture is then delivered to a tidally breathing patient at a controlled dosing rate and multi-minute treatment time.SAMi is developing this portable rescue device to treat severe bronchoconstriction as a first line emergency treatment to complement and enhance the activity of other drugs, particularly when conventional drugs have failed.This is the first time a therapeutic drug gas combines with a therapeutic drug vapor in a revolutionary portable delivery device to treat respiratory disease. ER -