PT  - JOURNAL ARTICLE
AU  - John Dennis
AU  - Andy Clark
AU  - Ian McAffer
AU  - Stefan Dalberg
AU  - Francis Green
TI  - First in class, respiratory drug gas & drug vapor delivered in a revolutionary and new portable device
AID  - 10.1183/13993003.congress-2015.PA4035
DP  - 2015 Sep 01
TA  - European Respiratory Journal
PG  - PA4035
VI  - 46
IP  - suppl 59
4099  - http://erj.ersjournals.com/content/46/suppl_59/PA4035.short
4100  - http://erj.ersjournals.com/content/46/suppl_59/PA4035.full
SO  - Eur Respir J2015 Sep 01; 46
AB  - Our drug-gas containing 8% CO2 in air combined with perfluorooctylbromide (Perflubron) vapor is being developed as a new class of fast acting bronchodilator drug working via unique biophysical mechanisms.The revolutionary portable delivery device incorporates separate storage of a compressed gas cylinder and a drug-liquid ampoule within the device body. On activation, compressed drug-gas is released through the liquid reservoir where perflubron vapor evaporates through an intermediate aerosol stage. The combined gas and vapor mixture is then delivered to a tidally breathing patient at a controlled dosing rate and multi-minute treatment time.SAMi is developing this portable rescue device to treat severe bronchoconstriction as a first line emergency treatment to complement and enhance the activity of other drugs, particularly when conventional drugs have failed.This is the first time a therapeutic drug gas combines with a therapeutic drug vapor in a revolutionary portable delivery device to treat respiratory disease.