RT Journal Article
SR Electronic
T1 LATE-BREAKING ABSTRACT: Overall survival after the introduction of CT-based follow-up after resection of lung cancer. A population based quality assurance analysis
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP OA264
DO 10.1183/13993003.congress-2015.OA264
VO 46
IS suppl 59
A1 Niels-Chr. G. Hansen
A1 Stefan Starup Jeppesen
A1 Erik Jakobsen
YR 2015
UL http://erj.ersjournals.com/content/46/suppl_59/OA264.abstract
AB The chance of having therapy with curative intent against recurrent lung cancer have increased more than three fold after the introduction of CT-based follow-up in Funen from mid-2010 (Eur Respir J September 2013; 42: 4828). All patients treated with curative intent are offered a contrast enhanced CT of thorax and upper abdomen every 3 months for two years and then every 6 months for three years. The aim of the present analysis was to explore the possible effect of the follow-up program on survival. By the Danish Lung Cancer Registry we have identified all 2512 patients from Funen (484,700 inhabitants) diagnosed in the 6 year period 2008 to 2013. In this period PET-CT and mediastinal evaluation by EBUS before surgery have been recommended in Denmark. In the 2½ years before the introduction of CT-based follow-up 158 patients (16.0%) were treated by resection (+/- chemo- and/or radiotherapy), while 233 (15.3%) have been treated in the 3½ years after. Vital status was updated as of May 15, 2015. We found a statistical significant difference between the survival curves for patients diagnosed before and after the introduction of the CT-based follow-up with observed 4-yr survival 55.7% vs. estimated 4-yr survival 67.8% (95%CI: 60.4-75.2%), p = 0,046 log rank test. By Cox regression adjusting for gender, age, FEV1, ECOG performance score, Charlson comorbidity index, disease stage, tumor size, and type of surgery the hazard rate (before vs. after the introduction of follow-up) was 0,69 (p=0.046). We conclude that the CT-based follow-up program most likely have caused the improved overall survival after surgery for lung cancer.