PT  - JOURNAL ARTICLE
AU  - Jefferson C.J. Aquino-Junior
AU  - Ana Roberta Almeida-Oliveira
AU  - Manoel C. Oliveira-Junior
AU  - Adilson S. Andrade-Sousa
AU  - Erasmo A. Neto
AU  - Auriléia Aparecida-Brito
AU  - Nicole C. Rigonato-Oliveira
AU  - Dioze Guadagnini
AU  - Luiz O. Leiria
AU  - Ana Paula L. De Oliveira
AU  - Mario J. Saad
AU  - Rodolfo P. Vieira
TI  - Aerobic exercise reduces pulmonary inflammation in diet-induced obesity in a HDM model of asthma through adipokines, IL-10, IL-17 and IL-23 signaling
AID  - 10.1183/13993003.congress-2015.PA4609
DP  - 2015 Sep 01
TA  - European Respiratory Journal
PG  - PA4609
VI  - 46
IP  - suppl 59
4099  - http://erj.ersjournals.com/content/46/suppl_59/PA4609.short
4100  - http://erj.ersjournals.com/content/46/suppl_59/PA4609.full
SO  - Eur Respir J2015 Sep 01; 46
AB  - Obesity is related with impaired lung function and inflammation and with increased incidence of asthma. Aerobic exercise (AE) reduces both obesity and airway inflammation, but never before the effects of AE on lung inflammation in a model of diet-induced obesity (DIO) and asthma was investigated. Forty C57Bl/6 male mice were distributed in Obese Control (OC), Obese Exercise (O+Ex), Obese+Asthma (O+As) and Obese+Asthma+Exercise (O+As+Ex) groups. Hypercaloric high fat diet was used initially for 10 weeks as a model of DIO and remained for more 7 weeks. Dermatophagoides pteronyssinus (HDM; 100ug/mouse; once a week on days 0, 7, 14, 21, 28, 35 and 42) was used as a model of asthma. Low intensity treadmill aerobic exercise was performed (1h/session, 5x/week, 4 weeks), beginning after the establishment of airway inflammation. AE reduced DIO+HDM-increased body mass (p<0.001) and total leukocytes (p<0.05), eosinophils (p<0.01), neutrophils (p<0.001), lymphocytes (p<0.001), macrophages (p<0.01) in bronchoalveolar lavage (BAL). AE reduced DIO+HDM-induced IL-5 (p<0.01), CXCL1/KC (p<0.05), IL-17 (p<0.001), IL-23 (p<0.001), TNF-alpha (p<0.001), while increased the anti-inflammatory cytokine IL-10 (p<0.05) in BAL. Of note, AE increased the levels of adiponectin in BAL (p<0.05) and in serum (p<0.05) in obese-sensitized mice and decreased the levels of leptin in BAL (p<0.05) and in serum (p<0.05). We conclude that AE reduces lung inflammation in diet-induced obesity in an asthma model by modulation of adipokines and by inhibition of IL-17 and IL-23 and by stimulation of IL-10 release.