TY - JOUR T1 - LATE-BREAKING ABSTRACT: Phenotypes of COPD in central and Eastern Europe - The POPE study JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2015.PA393 VL - 46 IS - suppl 59 SP - PA393 AU - Vladimir Koblizek AU - Ruzena Tkacova AU - Attila Somfay AU - Branislava Milenkovic AU - Adam Barczyk AU - Kirill Zykov AU - Neven Tudoric AU - Kosta Kostov AU - Zuzana Zbozinkova AU - Jan Svancara AU - Jurij Sorli AU - Alvis Krams AU - Marc Miravitlles AU - Arschang Valipour Y1 - 2015/09/01 UR - http://erj.ersjournals.com/content/46/suppl_59/PA393.abstract N2 - Introduction: Chronic obstructive pulmonary disease (COPD) represents a major health problem in Central and Eastern European (CEE) countries. However, data regarding symptom load and clinical phenotypes of patients with COPD in CEE remain largely unknown.Methods: Participation in the POPE Study (a multicentre, observational cross-sectional survey) was offered to consecutive outpatients with stable COPD in 11 CEE countries if they fulfilled the following criteria: age ≥ 40 years, smoking history ≥ 10 pack-years, post-bronchodilator (BD) FEV1/FVC < 0.7 and absence of COPD exacerbation ≥ 4 weeks.Results: 3504 patients (66 ± 8.7 yrs, 69% male, post-BD FEV1 53.0 ± 17.5% predicted, Charlson comorbidity index 2.0 ± 1.4, and 1.2 ± 1.6 exacerbations within the last 12 months) were recruited between Apr 2014 and May 2015. The majority of patients were classified as GOLD D or GOLD B (57% and 30.6% of total, respectively). According to predefined phenotypes, 63% of the population were non-exacerbators, 20.5% frequent exacerbators with chronic bronchitis (CB), 9.5% frequent exacerbators without CB, and 7% were patients with asthma-COPD overlap syndrome (ACOS). There were statistically significant differences in symptom load and lung function between these phenotypes. NON-exacerbatorsACOSFrequent exacerbators without CBFrequent exacerbators with CBp²CAT total¹15.8 (7.3)¨17.8 (7.8)¯18.2 (7.4)¯22.2 (7.5)°<0.001Post-bronchodilator FEV1¹55.8 (17.3)¯55.0 (17.6)¯45.5 (15.9)¨47.0 (16.1)¨<0.001¹Mean and standard deviation. ²One way ANOVA.¯,¨,° indicate homogenous groups (Tukey post hoc test).Conclusion: First results of the POPE study offer insight into symptom load, lung function, and phenotypes of COPD in CEE countries. ER -