RT Journal Article
SR Electronic
T1 Effect of inhaled beclomethasone or placebo on brain stem activity in a patient chronically treated with steroids - Preliminary report
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA1021
DO 10.1183/13993003.congress-2015.PA1021
VO 46
IS suppl 59
A1 Zygmunt Podolec
A1 Marcin Hartel
A1 Daria Panek
A1 Magdalena Podolec-Rubis
A1 Tomasz Banasik
YR 2015
UL http://erj.ersjournals.com/content/46/suppl_59/PA1021.abstract
AB Method: The study was conducted in women [aged 37] treated with steroids because of asthma in order to assess the activity of the brainstem. The study was conducted with the fMRI reader [3T GE] after the administration of beclomethasone(BC) at 250, 500 and 1000 µg or placebo. BC and placebo were administered every 14 days. To ensure the deposition of aerosol in the central-(CAD) or peripheral-(PAD) airways, applied inhalation chamber integrated with a spirometer [PNEUMOlogic® abcMED] was used. Data analysis was performed using FSL, ImageJ integrated program of anatomical atlases. The data were averaged over intervals of 5 minutes. The first 0-5 min interval taken as reference. Changing the strength of the signal was calculated in standard deviation units for each subsequent five minute period. Results: placebo and BC showed a decrease in signal strength after inhalation with a central deposition of aerosol. After inhalation, with a predominance of peripheral deposition (PAD) placebo showed an increase in signal, whereas 250, 500 and 1000 µg of BC was found dose-dependent decrease in the signal. Discussion: This is the first study to assess the impact of dose and space BC deposition on the function of selected brain structures. The study may be important for understanding the role of the knowledge of the brain and the need to harmonize the treatment of asthma with the brain.