RT Journal Article
SR Electronic
T1 Allergic comorbidities and lung function in adolescence - Data from the BAMSE cohort
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP OA1978
DO 10.1183/13993003.congress-2015.OA1978
VO 46
IS suppl 59
A1 Jenny Hallberg
A1 Natalia Ballardini
A1 Anna Bergström
A1 Per Gustafsson
A1 Inger Kull
A1 Gunnar Lilja
A1 Göran Pershagen
A1 Magnus Wickman
A1 Erik Melén
YR 2015
UL http://erj.ersjournals.com/content/46/suppl_59/OA1978.abstract
AB Background: Asthma in combination with rhinitis and eczema has been suggested to be associated with worse lung function than isolated asthma.Aim: To examine associations between asthma with and without rhinitis, eczema, allergic sensitization and; (1) spirometry, and (2) small airway involvement measured by impulse oscillometry (IOS).Methods: In the Swedish population-basedbirth cohort BAMSE (n= 4089), we used questionnaire data to identify children with rhinitis, eczema and asthma at 16 yrs. Sensitization was defined asspecific IgE ≥0.35 kUA/L. Subjects with asthma, with and without comorbidities, where compared to subjects without disease.Results: Asthma with and without rhinitis or eczema resulted in similar negative associations with FEV1/FVC (only asthma -2.6 %-units, 95% CI -3.9;-1.6, asthma + rhinitis -2.3, -3.4;-1.3). No significant associations were seen between isolated rhinitis/eczema and spirometric indices.Associations with increased peripheral resistance in the small airway resistance index R5-20 was observed only for asthma in combination with rhinitis, but not for isolated asthma, rhinitis or eczema.Further analyses to assess the relationship between small airway involvement, asthma, rhinitis and sensitization status showed significant associations with R5-20 only for asthma with sensitization, independent of rhinitis status (p= 0.438 for asthma + rhinitis without sensitization and p= 0.001 for asthma + rhinitis with sensitization).Conclusions: Asthma with allergic sensitization is associated with small airway involvement measured by IOS. Rhinitis and eczema did not alter the negative associations between asthma and lung function once sensitization was taken into account.