PT  - JOURNAL ARTICLE
AU  - Alice Claudia Repossi
AU  - Fabiano Di Marco
AU  - Emanuela Rancati
AU  - Mirta Cavallini
AU  - Fulvia Ribolla
AU  - Sara Job
AU  - Stefano Centanni
TI  - Identification of lung mechanical properties in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD)or acute heart failure (AHF) through forced oscillation technique (FOT): Preliminary results
AID  - 10.1183/13993003.congress-2015.PA4622
DP  - 2015 Sep 01
TA  - European Respiratory Journal
PG  - PA4622
VI  - 46
IP  - suppl 59
4099  - http://erj.ersjournals.com/content/46/suppl_59/PA4622.short
4100  - http://erj.ersjournals.com/content/46/suppl_59/PA4622.full
SO  - Eur Respir J2015 Sep 01; 46
AB  - In acute dyspnea differentiating between COPD exacerbations and acute heart failure represents an important clinical issue. Nowadays there are no accurate methods to discriminate the two diseases. Our hypothesis is that FOT allows to identify the different mechanical properties of both conditions.During the first day of hospitalization each patient underwent two FOT measurements in multifrequency (5-11-19 MHz) for two minutes at tidal volume in a sitting position. Three groups were evaluated: 11 patients with AECOPD (age 69±8 years, mean±SD, BMI 24,5±2,7 kg/m², FEV1 35±17% predicted); 11 patients with AHF, NYHA IV class (age 75±1, BMI 29,4 ± 8,1 kg/m²) and 6 healthy non-smoker subjects (mean age 63±3, BMI 27,7±5,0 kg/m², normal spirometry).All 28 subjects executed FOT with adequate compliance. 5-Hz resistance and reactance, 11 and 19-Hz reactance values were significantly increased in AECOPD compared to the other two groups (P<0,05). 11 and 19-Hz resistance values did not show significant differences between the three groups. Expiratory flow limitation (ΔXrs >2,81 cmH2O*s*L-1) distinguished AECOPD from the other two groups (P<0,05). FOT may permit accurate discrimination of AECOPD from AHF in hospitalized subjects with acute dyspnea, and should therefore be confirmed on a larger scale.