RT Journal Article SR Electronic T1 The comparison of serum visfatin levels in patients with acute PTE and non-PTE independent of BMI JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP PA2474 DO 10.1183/13993003.congress-2015.PA2474 VO 46 IS suppl 59 A1 Tutar, Nuri A1 Dogan, Serkan A1 Buyukoglan, Hakan A1 Sen, Ahmet A1 Yilmaz, Insu A1 Yildirim, Afra A1 Dogan, Ali A1 Yetkin, Aleyna A1 Oymak, Fatma sema A1 Gulmez, Inci A1 Demir, Ramazan YR 2015 UL http://erj.ersjournals.com/content/46/suppl_59/PA2474.abstract AB Background: Obesity is recognized as a major risk factor for thrombotic disorders such as cardiovascular disease, stroke, and venous thromboembolism.Objective: We aimed to compare the serum visfatin levels in patients with acute pulmonary thromboembolism (PTE) and non-PTE who had similar BMI.Design: We prospectively compared the serum visfatin levels of 49 acute PTE patients diagnosed by contrast-enhanced spiral computed chest tomography (CT) and 32 healthy volunteers. We also analyzed the short term mortality in the acute PTE group.Results: The visfatin level was lower in the PTE group than in the non-PTE group [6.2 ng/mL (IQR 4.9-8.7) and 6.7 ng/mL (IQR 5.0-8.9), respectively], but the difference was not statistically significant (p>0.05). Visfatin levels were higher in acute PTE patients with deep vein thrombosis (DVT) (n=18) than in those without DVT (n=31), but the difference was also statistically not significant [visfatin; 6.3 ng/mL (IQR 5.3-15.6) and 5.8 ng/mL (IQR 4.5-8.5), respectively, p>0.05]. The serum visfatin was not correlated with age, body mass index (BMI), highly sensitive C-reactive protein (hs-CRP), erythrocyte sedimentation rate (ESR) and white blood cell (WBC) count and D-dimer (p>0.05). All cause 30 day mortality rate was 4.1% (n=2) in the PTE group and visfatin levels were 30.1 ng/mL and 9.1 ng/mL in the two patients that died.Conclusions: Although the serum visfatin levels were lower in the acute PTE group than in the non-PTE group both of which had similar BMI, the difference was not statistically significant. Further and larger studies are needed to evaluate the visfatin levels in acute PTE.