RT Journal Article SR Electronic T1 Evaluation of lipoxin A4 and nitric oxide as inflammatory mediators in bronchial asthma JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP PA1067 DO 10.1183/13993003.congress-2015.PA1067 VO 46 IS suppl 59 A1 Fatema El Nokaly A1 Abd El Monem Elshabrawi A1 Hala El Mougy A1 Wafaa Abd El Fatah A1 Ashraf Behiry YR 2015 UL http://erj.ersjournals.com/content/46/suppl_59/PA1067.abstract AB Background: The delicate mechanisms of asthma involve the activation of many inflammatory and structural cells, all of which release inflammatory mediators that result in the typical pathophysiological changes of asthma.Aim of Work: The aim of this work is to assess lipoxin A4 and nitric oxide as mediators in bronchial asthma patients.Patients and methods: 75 patients with mild , moderate and severe asthma, 4th and 15 healthy volunteers as a control group. Determination of serum nitrites, enzyme immunoassay for serum lipoxin A4, and latex qualitative determination of serum C-reactive protein (CRP).Results: .View this table:Table 1 Serum levels of lipoxin A4 (ng/ml)Mean+/-SDFPSevere asthma60.64*#$ +/-15.0320.41<0.001Moderate asthma48.80*#+/-11.8120.41<0.001Mild asthma40.64*+/-12.4320.41<0.001Control group31.06+/-8.1320.41<0.001*=significant increase in nitrites in comparison to control group.#=significant increase in nitrites in comparison to mild asthma $=significant increase in nitrites in comparison to moderate asthmaConclusion: The low serum levels of lipoxin A4 and increased level of CRP and nitrites, emphasizes the rule of imbalance in inflammatory and anti-inflammatory cytokines in severity of asthma.