RT Journal Article
SR Electronic
T1 Health status predicts long-term outcomes in patients with chronic obstructive pulmonary disease (COPD): Pooled analysis of patient-level data from the COPD biomarker qualification consortium database
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA3017
DO 10.1183/13993003.congress-2015.PA3017
VO 46
IS suppl 59
A1 Hana Müllerová
A1 Heather Gelhorn
A1 Hilary Wilson
A1 Victoria Benson
A1 Niklas Karlsson
A1 Shailendra Menjoge
A1 Debora Merrill
A1 Stephen Rennard
A1 Ruth Tal-Singer
A1 Margaret Tabberer
A1 Paul Jones
YR 2015
UL http://erj.ersjournals.com/content/46/suppl_59/PA3017.abstract
AB Objective: Estimate predictive validity for health status measure, the St. George's Respiratory Questionnaire (SGRQ), among patients with COPD.Method: We used SGRQ data from the COPD Biomarker Qualification Consortium database of pooled individual patient data from medium term randomized clinical trials (N=12,043). Adjusted Hazard Ratios (HR) and 95% Confidence Intervals (95%CI) were used to estimate the association between quartiles of SGRQ at baseline, time to first event and time from first to second event for COPD exacerbations, hospital admissions for COPD, and all-cause death.Results: Risk of COPD outcomes increased with increasing quartiles of SGRQ score for all time to first event analyses; p for trend across quartiles <0.0001. Risk estimates for time to second event followed the same pattern; HR failed reaching statistical significance for hospital admissions .SGRQ quartile (score range)Exacerbation Recurrent Exacerbation Hospital admission Recurrent Hospital admission Mortality 1st (0<32)1.001.001.001.001.002nd (32<46)1.19 (1.11-1.28)1.18 (1.08-1.30)1.27 (1.11-1.44)1.10 (0.87-1.40)1.35 (1.11-1.64)3rd (46<60)1.28 (1.19-1.38)1.20 (1.09-1.32)1.53 (1.35-1.74)1.18 (0.94-1.50)1.71 (1.42-2.07)4th (=>60)1.40 (1.29-1.51)1.26 (1.14-1.40)2.01 (1.78-2.28)1.46 (1.16-1.83)2.30 (1.91-2.78)Risk of COPD outcomes by baseline SGRQ; HR (95% CI)Conclusion: In patients with COPD, SGRQ predicts long term outcomes of exacerbation of COPD, hospital admissions, their recurrence and death. Health status assessment should be a part of risk assessment for COPD patients in routine medical care.