RT Journal Article
SR Electronic
T1 Gastro-oesophageal dismotility measurements in scleroderma-associated interstitial lung disease: Correlation with respiratory and reflux symptoms
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA3805
DO 10.1183/13993003.congress-2015.PA3805
VO 46
IS suppl 59
A1 Angelo De Lauretis
A1 Dina Visca
A1 Simon Ward
A1 Claudia Clayman
A1 Charles Murray
A1 Ong Voon
A1 Christopher Denton
A1 Gisela Lindahl
A1 Carmel Stock
A1 Alfredo Chetta
A1 Marina Aiello
A1 Veronica Alfieri
A1 Michael Kreuter
A1 Wim Wuyts
A1 Toby Maher
A1 Athol U. Wells
A1 Elisabetta Renzoni
YR 2015
UL http://erj.ersjournals.com/content/46/suppl_59/PA3805.abstract
AB Background: Symptomatic gastro-oesophageal reflux [GORD] is reported in up to 90% of systemic sclerosis [SSc]. This study evaluates the potential relationship between GORD and respiratory symptoms and severity of SSc-associated interstitial lung disease [SSc-ILD].Material and methods: We present preliminary baseline results of the first 20 enrolled patients (median age 52, female 67%, median FVC=74%, median DLCO= 37%, diffuse SSc 33%) of a prospective study (NCT02136394), with regards to oesophageal manometry/24hr impedance (carried out off PPIs), respiratory(K-BILD and Leicester cough questionnaires) and GORD symptoms(UCLA SCTC GIT 2.0 Questionnaire, Reflux Disease Questionnaire RDQ) and lung function.Results: Proximal reflux was detected in 35% of patients, median DeMeester score was 19.1. DeMeester was higher in limited versus diffuse SSc(p=0.03), while it did not differ according to presence of extensive(FVC<70%) vs limited(FVC>70%) ILD. RDQ score was significantly correlated with DeMeester(r=0.7,p=0.003) and peristalsis failure(r=0.6, p=0.03); respiratory questionnaires showed correlations with nonacid proximal reflux episodes (K-BILD r=-0.7,p=0.03; Leicester r=-0.6,p=0.05) and cough-association to reflux (K-BILD r=0.7,p=0.02; Leicester r=0.6,p=0.05). Oesophageal tests and GORD questionnaire scores were not correlated with lung function parameters.Conclusions: We confirm an association between oesophageal dysmotility and respiratory symptoms in SSc-ILD. Larger numbers of patients followed up over time will need to be recruited to estimate the association between GORD measures and longitudinal changes in symptoms or severity of SSc-ILD.