PT  - JOURNAL ARTICLE
AU  - Angelo De Lauretis
AU  - Dina Visca
AU  - Simon Ward
AU  - Claudia Clayman
AU  - Charles Murray
AU  - Ong Voon
AU  - Christopher Denton
AU  - Gisela Lindahl
AU  - Carmel Stock
AU  - Alfredo Chetta
AU  - Marina Aiello
AU  - Veronica Alfieri
AU  - Michael Kreuter
AU  - Wim Wuyts
AU  - Toby Maher
AU  - Athol U. Wells
AU  - Elisabetta Renzoni
TI  - Gastro-oesophageal dismotility measurements in scleroderma-associated interstitial lung disease: Correlation with respiratory and reflux symptoms
AID  - 10.1183/13993003.congress-2015.PA3805
DP  - 2015 Sep 01
TA  - European Respiratory Journal
PG  - PA3805
VI  - 46
IP  - suppl 59
4099  - http://erj.ersjournals.com/content/46/suppl_59/PA3805.short
4100  - http://erj.ersjournals.com/content/46/suppl_59/PA3805.full
SO  - Eur Respir J2015 Sep 01; 46
AB  - Background: Symptomatic gastro-oesophageal reflux [GORD] is reported in up to 90% of systemic sclerosis [SSc]. This study evaluates the potential relationship between GORD and respiratory symptoms and severity of SSc-associated interstitial lung disease [SSc-ILD].Material and methods: We present preliminary baseline results of the first 20 enrolled patients (median age 52, female 67%, median FVC=74%, median DLCO= 37%, diffuse SSc 33%) of a prospective study (NCT02136394), with regards to oesophageal manometry/24hr impedance (carried out off PPIs), respiratory(K-BILD and Leicester cough questionnaires) and GORD symptoms(UCLA SCTC GIT 2.0 Questionnaire, Reflux Disease Questionnaire RDQ) and lung function.Results: Proximal reflux was detected in 35% of patients, median DeMeester score was 19.1. DeMeester was higher in limited versus diffuse SSc(p=0.03), while it did not differ according to presence of extensive(FVC<70%) vs limited(FVC>70%) ILD. RDQ score was significantly correlated with DeMeester(r=0.7,p=0.003) and peristalsis failure(r=0.6, p=0.03); respiratory questionnaires showed correlations with nonacid proximal reflux episodes (K-BILD r=-0.7,p=0.03; Leicester r=-0.6,p=0.05) and cough-association to reflux (K-BILD r=0.7,p=0.02; Leicester r=0.6,p=0.05). Oesophageal tests and GORD questionnaire scores were not correlated with lung function parameters.Conclusions: We confirm an association between oesophageal dysmotility and respiratory symptoms in SSc-ILD. Larger numbers of patients followed up over time will need to be recruited to estimate the association between GORD measures and longitudinal changes in symptoms or severity of SSc-ILD.