RT Journal Article
SR Electronic
T1 The burden of severe asthma in childhood and adolescence: results from the paediatric U-BIOPRED cohorts
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP ERJ-00780-2015
DO 10.1183/13993003.00780-2015
A1 Fleming, Louise
A1 Murray, Clare
A1 Bansal, Aruna T.
A1 Hashimoto, Simone
A1 Bisgaard, Hans
A1 Bush, Andrew
A1 Frey, Urs
A1 Hedlin, Gunilla
A1 Singer, Florian
A1 van Aalderen, Wim M.
A1 Vissing, Nadja H.
A1 Zolkipli, Zaraquiza
A1 Selby, Anna
A1 Fowler, Stephen
A1 Shaw, Dominick
A1 Chung, Kian Fan
A1 Sousa, Ana R.
A1 Wagers, Scott
A1 Corfield, Julie
A1 Pandis, Ioannis
A1 Rowe, Anthony
A1 Formaggio, Elena
A1 Sterk, Peter J.
A1 Roberts, Graham
YR 2015
UL http://erj.ersjournals.com/content/early/2015/09/24/13993003.00780-2015.abstract
AB U-BIOPRED aims to characterise paediatric and adult severe asthma using conventional and innovative systems biology approaches.A total of 99 school-age children with severe asthma and 81 preschoolers with severe wheeze were compared with 49 school-age children with mild/moderate asthma and 53 preschoolers with mild/moderate wheeze in a cross-sectional study.Despite high-dose treatment, the severe cohorts had more severe exacerbations compared with the mild/moderate ones (annual medians: school-aged 3.0 versus 1.1, preschool 3.9 versus 1.8; p<0.001). Exhaled tobacco exposure was common in the severe wheeze cohort. Almost all participants in each cohort were atopic and had a normal body mass index. Asthma-related quality of life, as assessed by the Paediatric Asthma Quality of Life Questionnaire (PAQLQ) and the Paediatric Asthma Caregiver's Quality of Life Questionnaire (PACQLQ), was worse in the severe cohorts (mean±se school-age PAQLQ: 4.77±0.15 versus 5.80±0.19; preschool PACQLQ: 4.27±0.18 versus 6.04±0.18; both p≤0.001); however, mild/moderate cohorts also had significant morbidity. Impaired quality of life was associated with poor control and airway obstruction. Otherwise, the severe and mild/moderate cohorts were clinically very similar.Children with severe preschool wheeze or severe asthma are usually atopic and have impaired quality of life that is associated with poor control and airflow limitation: a very different phenotype from adult severe asthma. In-depth phenotyping of these children, integrating clinical data with high-dimensional biomarkers, may help to improve and tailor their clinical management.Children with severe preschool wheeze or severe asthma are usually atopic and have impaired quality of life http://ow.ly/RrrGE