PT  - JOURNAL ARTICLE
AU  - Marianne Paesmans
AU  - Camilo Garcia
AU  - Ching-Yee Oliver Wong
AU  - Edward F. Patz, Jr
AU  - Ritsuko Komaki
AU  - Susanne Eschmann
AU  - Ramaswamy Govindan
AU  - Johan Vansteenkiste
AU  - Anne-Pascale Meert
AU  - Wouter K. de Jong
AU  - Nasser Khaled Altorki
AU  - Kotaro Higashi
AU  - Angela Van Baardwijk
AU  - Gerben R. Borst
AU  - Lieveke Ameye
AU  - Jean-Jacques Lafitte
AU  - Thierry Berghmans
AU  - Patrick Flamen
AU  - Ramon Rami-Porta
AU  - Jean-Paul Sculier
TI  - Primary tumour standardised uptake value is prognostic in nonsmall cell lung cancer: a multivariate pooled analysis of individual data
AID  - 10.1183/13993003.00099-2015
DP  - 2015 Sep 24
TA  - European Respiratory Journal
PG  - ERJ-00099-2015
4099  - http://erj.ersjournals.com/content/early/2015/09/24/13993003.00099-2015.short
4100  - http://erj.ersjournals.com/content/early/2015/09/24/13993003.00099-2015.full
AB  - 18F-fluoro-2-deoxy-d-glucose positron emission tomography (PET) complements conventional imaging for diagnosing and staging lung cancer. Two literature-based meta-analyses suggest that maximum standardised uptake value (SUVmax) on PET has univariate prognostic value in nonsmall cell lung cancer (NSCLC). We analysed individual data pooled from 12 studies to assess the independent prognostic value of binary SUVmax for overall survival.After searching the published literature and identifying unpublished data, study coordinators were contacted and requested to provide data on individual patients. Cox regression models stratified for study were used.Data were collected for 1526 patients (median age 64 years, 60% male, 34% squamous cell carcinoma, 47% adenocarcinoma, 58% stage I–II). The combined univariate hazard ratio for SUVmax was 1.43 (95% CI 1.22–1.66) and nearly identical if the SUV threshold was calculated stratifying for histology. Multivariate analysis of patients with stage I–III disease identified age, stage, tumour size and receipt of surgery as independent prognostic factors; adding SUV (HR 1.58, 95% CI 1.27–1.96) improved the model significantly. The only detected interaction was between SUV and stage IV disease.SUV seems to have independent prognostic value in stage I–III NSCLC, for squamous cell carcinoma and for adenocarcinoma.SUV has independent prognostic value in stage I–III NSCLC, both for squamous cell carcinoma and for adenocarcinoma http://ow.ly/Q2FKI