TY - JOUR T1 - Effects of ageing and smoking on pulmonary computed tomography scans using parametric response mapping JF - European Respiratory Journal JO - Eur Respir J SP - 1193 LP - 1196 DO - 10.1183/09031936.00009415 VL - 46 IS - 4 AU - Ilse M. Boudewijn AU - Dirkje S. Postma AU - Eef D. Telenga AU - Nick H.T. ten Hacken AU - Wim Timens AU - Matthijs Oudkerk AU - Brian D. Ross AU - Craig J. Galbán AU - Maarten van den Berge Y1 - 2015/10/01 UR - http://erj.ersjournals.com/content/46/4/1193.abstract N2 - Chronic obstructive pulmonary disease (COPD) is an obstructive lung disease often caused by cigarette smoke, and characterised by inflammation and abnormalities of the large and small airways (i.e. those with an internal diameter <2 mm), as well as by alveolar destruction (emphysema). Recent evidence suggests that small airway disease precedes emphysema [1] and, therefore, it may be useful to identify the presence and extent of small airway disease and emphysema in early COPD, or preferably, even before the onset of disease.Parametric response mapping can distinguish small airway disease, emphysema and parenchymal disease on pulmonary CT http://ow.ly/Neuw6The authors thank Jennifer Boes (Department of Radiology and Center for Molecular Imaging, University of Michigan, Ann Arbor, MI, USA) for optimising the registration algorithm used for the PRM analysis. ER -