PT  - JOURNAL ARTICLE
AU  - Rosa Faner
AU  - Alba Gutiérrez-Sacristán
AU  - Ady Castro-Acosta
AU  - Solène Grosdidier
AU  - Wenqi Gan
AU  - Milagros Sánchez-Mayor
AU  - Jose Luis Lopez-Campos
AU  - Francisco Pozo-Rodriguez
AU  - Ferran Sanz
AU  - David Mannino
AU  - Laura I. Furlong
AU  - Alvar Agusti
TI  - Molecular and clinical diseasome of comorbidities in exacerbated COPD patients
AID  - 10.1183/13993003.00763-2015
DP  - 2015 Oct 01
TA  - European Respiratory Journal
PG  - 1001--1010
VI  - 46
IP  - 4
4099  - http://erj.ersjournals.com/content/46/4/1001.short
4100  - http://erj.ersjournals.com/content/46/4/1001.full
SO  - Eur Respir J2015 Oct 01; 46
AB  - The frequent occurrence of comorbidities in patients with chronic obstructive pulmonary disease (COPD) suggests that they may share pathobiological processes and/or risk factors.To explore these possibilities we compared the clinical diseasome and the molecular diseasome of 5447 COPD patients hospitalised because of an exacerbation of the disease. The clinical diseasome is a network representation of the relationships between diseases, in which diseases are connected if they co-occur more than expected at random; in the molecular diseasome, diseases are linked if they share associated genes or interaction between proteins.The results showed that about half of the disease pairs identified in the clinical diseasome had a biological counterpart in the molecular diseasome, particularly those related to inflammation and vascular tone regulation. Interestingly, the clinical diseasome of these patients appears independent of age, cumulative smoking exposure or severity of airflow limitation.These results support the existence of shared molecular mechanisms among comorbidities in COPD.Half of the comorbidities observed in COPD patients hospitalised by an exacerbation share common molecular mechanisms http://ow.ly/PDiGg